Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: Incidence and risk factors
Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: Incidence and risk factors
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DOI：
10.1055/s-2007-993889
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发表时间：
1998-01-01
影响因子：
2
通讯作者：
Malloy, MH
中科院分区：
文献类型：
--
作者：
Alagappan, A;Malloy, MH
本研究的目的是确定出生体重小于1250 g（极低出生体重[VLBW]婴儿）的全身性高血压（HTN）是否与支气管肺发育不良（BPD）相关。我们设计了一项历史性队列研究，以回顾1992年出生的出生体重在600-1250 g之间的婴儿的临床病程和全身HTN的发生率。HTN的总发病率为6.8%（5/73），BPD婴儿的发病率为12%（5/41）。HTN的平均发病年龄为105天（范围为90 - 133天），出院时，5名婴儿中有3名（60%）仍有高血压，5名婴儿中有3名（60%）正在补充氧气。所有5名高血压婴儿（100%）在产后36周时都接受了辅助供氧，而36名非高血压BPD婴儿中有18名（50%）接受了辅助供氧。HTN和严重BPD之间的相关性进一步表现为较长的住院时间（145 +/- 37 vs. 94 +/- 28天，p = 0.004），O-2治疗持续时间更长（108 +/- 36 vs. 67 +/- 34天，p = 0.01）和长期使用氨茶碱（104 +/- 44 vs. 61 +/- 23天，p = 0.03）。本研究证实，在患有重度BPD的极低出生体重婴儿中，发生全身性HTN的风险增加。
The purpose of our study was to determine if systemic hypertension (HTN) occurred among infants with birth weight less than 1250 g (very low-birth-weight [VLBW] infants) in association with Bronchopulmonary dysplasia (BPD). We designed a historical cohort study to review the clinical course and the occurrence of systemic HTN in infants born during the year 1992 with birth weights between 600-1250 g. The overall incidence of HTN was 6.8% (5 of 73) and the incidence in infants with BPD was 12% (5 of 41). The mean age of onset of HTN was 105 days (range 90 to 133 days), and at the time of discharge 3 of 5 (60%) infants remained hypertensive and 3 of 5 (60%) were on supplemental oxygen. All the five hypertension infants (100%) were on supplemental oxygen at 36 weeks of postceptional age compared to 18 of 36 (50%) of nonhypertensive BPD infants. The association between HTN and severe BPD was further denoted by longer hospital stay (145 +/- 37 vs. 94 +/- 28 days, p = 0.004), longer duration of O-2 therapy (108 +/- 36 vs. 67 +/- 34 days, p = 0.01), and prolonged use of aminophylline (104 +/- 44 vs, 61 +/- 23 days, p = 0.03), in the hypertensive BPD infants versus nonhypertensive BPD infants, respectively. This study substantiates an increased risk of developing systemic HTN, among VLBW infants with severe BPD.