An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
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DOI：
10.3791/50829
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发表时间：
2014-02-01
影响因子：
1.2
通讯作者：
Schneider, Bianca E.
中科院分区：
文献类型：
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作者：
Mueller, Ann-Kristin;Behrends, Jochen;Schneider, Bianca E.
由于不同类型的病原生物体的地理重叠，合并感染自然发生。并发感染最可能调节对每种单一病原体的相应免疫应答，从而可能影响发病机制和疾病结局。合并感染的患者也可能对抗感染干预的反应不同。由分枝杆菌引起的结核病和疟疾寄生虫疟原虫之间的合并感染，这两者在撒哈拉以南非洲的许多地区共同流行，尚未详细研究。为了接近具有挑战性的，但科学和临床高度相关的问题，疟疾-结核病合并感染如何调节宿主免疫力和每种疾病的病程，我们建立了一个实验小鼠模型，使我们能够解剖引起的免疫反应，这两种病原体在合并感染的主机。值得注意的是，为了最精确地模拟自然获得的人类感染，我们用两种病原体通过它们的自然感染途径，即分别通过气溶胶和蚊子叮咬，对小鼠进行实验感染。
Coinfections naturally occur due to the geographic overlap of distinct types of pathogenic organisms. Concurrent infections most likely modulate the respective immune response to each single pathogen and may thereby affect pathogenesis and disease outcome. Coinfected patients may also respond differentially to anti-infective interventions. Coinfection between tuberculosis as caused by mycobacteria and the malaria parasite Plasmodium, both of which are coendemic in many parts of sub-Saharan Africa, has not been studied in detail. In order to approach the challenging but scientifically and clinically highly relevant question how malaria-tuberculosis coinfection modulate host immunity and the course of each disease, we established an experimental mouse model that allows us to dissect the elicited immune responses to both pathogens in the coinfected host. Of note, in order to most precisely mimic naturally acquired human infections, we perform experimental infections of mice with both pathogens by their natural routes of infection, i.e. aerosol and mosquito bite, respectively.