Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
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DOI：
10.1016/j.neurobiolaging.2010.11.015
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发表时间：
2012-07-01
影响因子：
4.2
通讯作者：
Lee, Phil Hyu
中科院分区：
文献类型：
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作者：
Choi, Seo Hee;Jung, Tae Min;Lee, Phil Hyu
起源于基底前脑无名质（substantia innominata，SI）的胆碱能系统在帕金森病（Parkinson's disease，PD）的认知功能中具有重要作用。我们进行了基于磁共振成像的体积分析，以评估PD-完整认知（PD-IC），PD-轻度认知障碍（PD-MCI）和PD痴呆（PDD）患者的SI体积。与对照组（1.68 +/- 0.11）相比，PD-IC（1.54 +/- 0.12，p <0.001）、PD-MCI（1.49 +/- 0.12，p < 0.001）和PDD（1.39 +/- 0.12，p < 0.001）患者的平均标准化SI体积显著降低。PD-IC和PD-MCI患者之间的标准化SI体积没有差异;然而，与PD-IC（p < 0.001）或PD-MCI（p = 0.016）患者相比，PDD患者的标准化SI体积显著降低。标准化SI体积与一般认知状态（r = 0.51，p < 0.001）以及每个认知子域的表现显著相关，与注意力（beta = 0.33，p = 0.003）和物体命名（beta = 0.26，p = 0.017）的独立关联特别显著。本研究表明，PD患者的SI体积因认知状态而异，并与认知表现显著相关。(C)2012 Elsevier Inc. All rights reserved.
The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 +/- 0.12, p < 0.001), PD-MCI (1.49 +/- 0.12, p < 0.001), and PDD (1.39 +/- 0.12, p < 0.001) compared with that of control subjects (1.68 +/- 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (beta = 0.33, p = 0.003) and object naming (beta = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance. (C) 2012 Elsevier Inc. All rights reserved.