Erythropoiesis and iron
Erythropoiesis and iron
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DOI：
10.1053/beha.2002.0004
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发表时间：
2002-06-01
影响因子：
2.1
通讯作者：
Cavill, I
中科院分区：
文献类型：
--
作者：
Cavill, I
铁和红细胞生成是密不可分的。红细胞生成是一个动态的过程，每天需要30-40毫克的铁。在正常情况下，这是由红细胞破坏引起的，但在贫血症中，情况并非如此。铁储备减少会限制成红细胞的铁供应，但正常或升高的铁储备可能无法足够快地供应铁。当骨髓被促红细胞生成素刺激时尤其如此;最常见的失败原因是“功能性缺铁”。虽然血红蛋白和血清铁蛋白浓度反映了主要的铁池，但红系细胞的铁供应只能通过测量循环中低色素红细胞的百分比来评估。
Iron and erythropoiesis are inextricably linked. Erythropoiesis is a dynamic process that requires 30-40 mg of iron per day. In normal circumstances this is met from red cell destruction but in anaemia this will not be the case. Reduced iron stores will limit iron supply to erythroblasts but normal or raised iron stores may not be able to supply iron fast enough. This is particularly true when the marrow is stimulated by erythropoietin therapy; the most common cause of failure to respond is 'functional iron deficiency'. This entity can only be effectively addressed by intravenous iron therapy.While haemoglobin and serum ferritin concentrations reflect the major iron pools, iron supply to erythroid cells can only be assessed by measuring effective haemoglobinization through the percentage of hypochromic red cells in the circulation.