Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study
Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study
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DOI：
10.1136/thx.2009.115931
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发表时间：
2009-09-01
期刊：
影响因子：
10
通讯作者：
Hirota, Y.
中科院分区：
文献类型：
--
作者：
Miyake, Y.;Sasaki, S.;Hirota, Y.
背景：能够调节产前免疫应答的一个因素是饮食。这项前瞻性研究探讨了母亲在怀孕期间摄入特定类型的脂肪酸，胆固醇，鱼和肉之间的关联和喘息和湿疹的风险在后代。母亲在怀孕期间摄入的数据进行了评估与饮食史问卷。根据儿童哮喘和过敏症国际研究的标准，从产后16-24个月的母亲完成的问卷中获得喘息和湿疹的数据。母亲在怀孕期间摄入较高的α-亚麻酸和二十二碳六烯酸与喘息风险降低独立相关，但与湿疹无关，在后代中（极端四分位数之间的调整后比值比（OR）分别为0.52（95%CI 0.28至0.97）和0.37（95%CI 0.15至0.91）。母亲在怀孕期间摄入较多的n-6多不饱和脂肪酸和亚油酸与婴儿湿疹风险增加独立相关，但与喘息无关（校正OR分别为2.25（95%CI 1.13至4.54）和2.11（95%CI 1.06至4.26））。在孕妇总脂肪、饱和脂肪酸、单不饱和脂肪酸、二十碳五烯酸、花生四烯酸、胆固醇、肉类和鱼类的摄入量以及孕期n-3与n-6多不饱和脂肪酸摄入量的比例与婴儿喘息或湿疹之间没有观察到显著的因果关系。母亲在怀孕期间摄入α-亚麻酸和二十二碳六烯酸可以预防婴儿喘息。母亲在怀孕期间摄入n-6多不饱和脂肪酸，特别是亚油酸，可能会增加儿童湿疹的风险。
Background: One factor capable of modulating antenatal immune responses is diet. This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring.Methods: Subjects were 763 mother-child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on wheeze and eczema based on criteria of the International Study of Asthma and Allergies in Childhood were obtained from a questionnaire completed by mothers 16-24 months postpartum.Results: Higher maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy was independently associated with a reduced risk of wheeze, but not eczema, in the offspring (adjusted odds ratios (ORs) between extreme quartiles 0.52 (95% CI 0.28 to 0.97) and 0.37 (95% CI 0.15 to 0.91), respectively). Higher maternal intake of n-6 polyunsaturated fatty acids and linoleic acid during pregnancy was independently related to an increased risk of infantile eczema but not wheeze (adjusted ORs 2.25 (95% CI 1.13 to 4.54) and 2.11 (95% CI 1.06 to 4.26), respectively). No significant exposure-response relationships were observed between maternal consumption of total fat, saturated fatty acids, mono-unsaturated fatty acids, eicosapentaenoic acid, arachidonic acid, cholesterol, meat and fish and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption during pregnancy and infantile wheeze or eczema.Conclusions: Maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy may be preventive against infantile wheeze. Maternal intake of n-6 polyunsaturated fatty acids, especially linoleic acid, during pregnancy may increase the risk of childhood eczema.