Effect of duodenal bile acid delivery on fasting intestinal motor activity.
Effect of duodenal bile acid delivery on fasting intestinal motor activity.
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十二指肠胆汁酸输送对空腹肠运动活动的影响。
DOI：
10.1152/ajpgi.1986.250.6.g836
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Scott
中科院分区：
文献类型：
--
作者：
R. Scott
空腹十二指肠胆汁酸输送是脉动的，并与十二指肠移行性肌电复合体（MMC）周期性协调。为了确定十二指肠胆汁酸输送是否影响MMC的十二指肠周期（CP）或十二指肠运动活动的强度，为三只犬准备了十二指肠插管，允许胆总管插管、十二指肠输注和测压。在肝肠循环完整的情况下，并在胆总管插管后，在连续十二指肠输注（1.6 ml/min）0、2.5、12.5或25 mM牛磺胆酸钠的154 mM NaCl溶液期间，从十二指肠转移内源性胆汁，测量CP。在肝肠循环完整的第二个方案中，测量对照和后续CP，并将合并的犬胆汁（112 mM总胆汁酸）或154 mM NaCl中的0、20、80或140 mM牛磺胆酸钠脉冲（1 ml/min，持续10 min）以第二个CP的40%（根据对照CP估计）输注到十二指肠中。计算从对照CP的40%开始到随后CP中脉冲输注开始的间隔的运动指数。与连续十二指肠灌注牛磺胆酸钠相比，肝肠循环完整时CP无显著差异。过早脉冲输注牛磺胆酸钠或合并犬胆汁后，CP或运动指数无显著变化。十二指肠胆汁酸输送的变化并没有调节十二指肠运动活动或MMC循环的强度。
Fasting duodenal bile acid delivery is pulsatile and is cyclically coordinated with the duodenal migrating myoelectric complex (MMC). To determine whether duodenal bile acid delivery influences the duodenal cycle period (CP) of the MMC or the intensity of duodenal motor activity, three dogs were prepared with a duodenal cannula, permitting cannulation of the common bile duct, duodenal infusion, and manometry. CP was measured with the enterohepatic circulation intact and after the common bile duct was cannulated to divert endogenous bile from the duodenum during continuous duodenal infusion (1.6 ml/min) of 0, 2.5, 12.5, or 25 mM sodium taurocholic acid in 154 mM NaCl. During a second protocol with the enterohepatic circulation intact, a control and subsequent CP were measure, and a pulse (1 ml/min for 10 min) of pooled dog bile (112 mM total bile acids) or 0, 20, 80, or 140 mM sodium taurocholic acid in 154 mM NaCl was infused into the duodenum at 40% of the second CP (as estimated from control CP). A motility index was calculated for an interval commencing at 40% of the control CP and at the start of pulse infusion in the succeeding CP. There was no significant difference in CP with the enterohepatic circulation intact compared with that during continuous duodenal infusion of sodium taurocholic acid. There was no significant change in CP or motility index after premature pulse infusion of sodium taurocholic acid or pooled dog bile. Variation in duodenal bile acid delivery did not modulate intensity of duodenal motor activity or cycling of the MMC.