MMPS, TIMP-2, and TGF-β1 in the cancerization of oral lichen planus
MMPS, TIMP-2, and TGF-β1 in the cancerization of oral lichen planus
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DOI：
10.1002/hed.20869
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发表时间：
2008-09-01
影响因子：
2.9
通讯作者：
Windsor, Lester Jack
中科院分区：
文献类型：
--
作者：
Chen, Yu;Zhang, Weiping;Windsor, Lester Jack
背景基质金属蛋白酶（MMPs）和转化生长因子-β 1（TGF-β 1）在许多生理和病理过程中起重要作用。应用免疫组化法检测正常口腔黏膜、非萎缩性口腔扁平苔藓、萎缩性口腔扁平苔藓及扁平苔藓引起的口腔鳞状细胞癌（OSCC）中MMP-2、MMP-9、膜型1型MMP（MT 1-MMP、MMP-14）、基质金属蛋白酶组织抑制剂（TIMP）-2和TGF-β的表达。MMPs的表达从正常粘膜到非萎缩性口腔扁平苔藓、萎缩性口腔扁平苔藓和OSCC逐渐增加。萎缩性口腔扁平苔藓中MMPs的免疫组化评分显著高于非萎缩性口腔扁平苔藓。MMP-9在口腔鳞状细胞癌中的表达明显高于萎缩性和非萎缩性扁平苔藓。此外，MMP-2和TGF-β 1的表达增加。MMPs和TIMPs的失衡可能参与口腔扁平苔藓的癌变过程。MMP-2、MT 1-MMP、尤其是MMP-9可作为判断口腔扁平苔藓恶变的有效指标。(c)2008 Wiley Periodicals，Inc.
Background. Matrix metalloproteinases (MMPs) and transforming growth factor-pi (TGF-beta 1) are important in many physiological and pathological processes.Methods. Immunohistochemistry for MMP-2, MMP-9, membrane-type 1 MMP (MT1-MMP, MMP-14), tissue inhibitor of matrix metalloproteinase (TIMP)-2, and TGF-beta were performed on normal mucosa, nonatrophic oral lichen planus, atrophic oral lichen planus, and oral squamous cell carcinomas (OSCC) resulting from lichen planus.Results. Expression of MMPs progressively increased from normal mucosa to nonatrophic oral lichen planus, atrophic oral lichen planus, and OSCCs. Immunoscores of MMPs in atrophic oral lichen planus was significantly greater than nonatrophic oral lichen planus. Moreover, immunoscore of MMP-9 of OSCCs was significantly greater than both atrophic and nonatrophic lichen planus. Furthermore, expression of TIMP-2 and TGF-beta 1 paralleled increases seen with MMPs.Conclusions. Imbalance between MMPs and TIMPs may be involved in cancerization of oral lichen planus. MMP-2, MT1-MMP, and especially MMP-9 may be useful markers for judging potency of malignant transformation from oral lichen planus. (c) 2008 Wiley Periodicals, Inc.