Phyto-oestrogens and osteoporosis: what is a safe dose?
Phyto-oestrogens and osteoporosis: what is a safe dose?
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DOI：
10.1079/bjn2002800
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Barnes, S
中科院分区：
文献类型：
--
作者：
Barnes, S
激素替代疗法(HRT)用于预防绝经后骨质丢失，只有8%-10%的潜在使用者使用，主要是因为担心乳腺癌风险增加。植物雌激素类化合物(植物雌激素)已被提出作为HRT的替代品来预防骨质疏松。有一类植物雌激素(异黄酮类)存在于大豆食品和红三叶草中。食品工业正在开发各种含有大豆的新食品，以大幅增加异黄酮的摄入量，并从大豆和三叶草中提取异黄酮，用作非大豆食品的添加剂。制药公司也在准备以药丸形式使用的异黄酮萃取物。在每种情况下，靶向给药类似于每天50毫克的异黄酮类药物。这个剂量的异黄酮类药物安全吗？在对当前文献的回顾中，结论是口服和剂量低于每天2毫克/公斤体重的异黄酮类药物对大多数人群来说应该是安全的。这些剂量是否足以预防骨质疏松症是另一回事。
Hormone replacement therapy (HRT) for preventing loss of bone following the menopause is utilised by only 8-10% of possible users, largely due to a fear of increased risk of breast cancer. Plant oestrogen-like compounds (phyto-oestrogens) have been proposed as an alternative to HRT to prevent osteoporosis. One class of phyto-oestrogens (the isoflavones) is found in soya foods and red clover. The food industry is developing a wide variety of new foods containing soya to substantially increase isoflavone intake, as well as extracting isoflavones from soya and clover to use as additives to non-soya foods. Pharmaceutical companies are also preparing isoflavone extracts to be used in pill form. In each case the targeted delivery is similar to50 mg of isoflavones/d. Is this dose of isoflavones safe? In this review of the current literature, it is concluded that isoflavones consumed orally and in doses below 2 mg/kg body weight per d should be considered safe for most population groups. Whether these doses are sufficient to prevent osteoporosis is a separate matter.