Limbic activation to cigarette smoking cues independent of nicotine withdrawal: A perfusion fMRI study
Limbic activation to cigarette smoking cues independent of nicotine withdrawal: A perfusion fMRI study
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DOI：
10.1038/sj.npp.1301371
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发表时间：
2007-11-01
影响因子：
7.6
通讯作者：
Childress, Anna Rose
中科院分区：
文献类型：
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作者：
Franklin, Teresa R.;wang, Ze;Childress, Anna Rose
暴露在吸烟线索中会引发生理唤醒和吸烟欲望。吸烟线索诱导的渴求(CIC)的大脑底物已经开始被阐明；然而，如果不考虑尼古丁的药物戒断的潜在作用，就很难研究这种状态。药物戒断本身可能通过掩盖或加强线索对大脑的激活产生实质性影响，由于尼古丁替代策略不会降低CIC，其神经解剖学基础可能不同。因此，确定CIC的特征对于制定有效的干预措施至关重要。这项研究使用动脉自旋标记(ASL)灌注功能磁共振成像，以及新开发的高食欲、明确的吸烟刺激，在一个原始的实验设计中检查了香烟CIC的神经活动，该实验设计强烈地减少了药物戒断的贡献。21名吸烟者(12名女性)完成了吸烟和不吸烟提示功能磁共振成像课程。在每次治疗前和治疗后收集渴望自我报告。采用SPM2软件进行数据分析。在暴露于吸烟刺激期间，在腹侧纹状体、杏仁核、眶前皮质、海马体、内侧丘脑和左侧脑岛，先验选定区域的血流(灌注量)比非吸烟刺激(p<；0.01；校正)更大。在背外侧额叶皮质(r(2)=0.54)和后扣带回(r(2)=0.53)，CIC的灌注量与香烟的CIC强度呈正相关。这种激活模式包括腹侧纹状体，关键的奖励底物，以及相互联系的杏仁核、扣带核和OFC，这与数十年来动物对条件药物奖励的神经关联的研究是一致的。
Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers ( 12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow ( perfusion) in a priori-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (p < 0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (r(2) = 0.54) and posterior cingulate (r(2) = 0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward.