Reduction of activated conjugated alkenes by the InCl3-NaBH4 reagent system
Reduction of activated conjugated alkenes by the InCl3-NaBH4 reagent system
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DOI：
10.1016/j.tet.2003.08.022
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发表时间：
2003-09-29
期刊：
影响因子：
2.1
通讯作者：
Samanta, S
中科院分区：
文献类型：
--
作者：
Ranu, BC;Samanta, S
在乙腈中催化量的氯化铟和硼氢化钠的组合选择性地减少共轭烯烃中的碳-碳双键，如α，α-二氰基烯烃，α，β-不饱和腈，氰酸酯，氰磷酸盐和二元酸酯。然而，查尔酮的减少并没有什么不同。如果反应混合物用水淬灭，则它们被还原为饱和酮和醇的混合物，而用甲醇淬灭只生成饱和醇。(C)2003爱思唯尔有限公司。保留所有权利。
A combination of a catalytic amount of indium (III) chloride and sodium borohydride in acetonitrile reduces selectively the carbon-carbon double bonds in conjugated alkenes such as alpha,alpha-dicyano olefins, alpha,beta-unsaturated nitriles, cyanoesters, cyanophosphonate and dicarboxylic esters. However, reduction of chalcones is little different. They are reduced to a mixture of saturated ketones and alcohols if the reaction mixture is quenched with H2O, whereas quenching with MeOH leads to saturated alcohols only. (C) 2003 Elsevier Ltd. All rights reserved.