Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion.
Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion.
复制标题
脑肾素-血管紧张素系统和脑前列腺素之间的相互作用在控制加压素分泌中。
DOI：
10.1007/bf00232201
复制
发表时间：
1990
影响因子：
2
通讯作者：
Share,L
中科院分区：
文献类型：
--
作者：
Inoue,M;Crofton,JT;Share,L
Experiments were carried out in conscious, unrestrained, male rats to evaluate possible interactions between brain prostanoids and the brain renin-angiotensin system in the control of vasopressin release and in cardiovascular regulation. The intracerebroventricular (icv) administration of prostaglandin D2(PGD2) resulted in transient increases in the plasma vasopressin concentration (PAVP) and heart rate and a gradual increase in mean arterial blood pressure (MABP). Pretreatment icv with saralasin, an angiotensin II-receptor antagonist, moderately attenuated the vasopressin response to PGD2, but had no effect on the heart rate and blood pressure responses. Angiotensin II icv increased both PAVPand MABP. This vasopressin response was almost completely prevented by prior icv meclofenamate, a cyclooxygenase inhibitor, and the blood pressure response was attenuated. These observations, combined with previous studies of the role of central angiotensin II and central prostanoids in the physiological control of vasopressin release, suggest that there may be important interactions between brain prostanoids and the brain renin-angiotensin system in this control.
