Bone cell proliferation on carbon nanotubes
Bone cell proliferation on carbon nanotubes
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DOI：
10.1021/nl051861e
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发表时间：
2006-03-01
期刊：
影响因子：
10.8
通讯作者：
Haddon, RC
中科院分区：
文献类型：
--
作者：
Zanello, LP;Zhao, B;Haddon, RC
我们探索使用碳纳米管（CNT）作为成骨细胞增殖和骨形成的合适支架材料。为了控制细胞生长，骨肉瘤 ROS 17/2.8 细胞在化学修饰的单壁 (SW) 和多壁 (MW) 碳纳米管上培养。携带中性电荷的碳纳米管维持了最高的细胞生长和板状晶体的产量。在 MWNT 上培养的成骨细胞的细胞形态发生了巨大的变化，这与质膜功能的变化相关。
We explored the use of carbon nanotubes (CNTs) as suitable scaffold materials for osteoblast proliferation and bone formation. With the aim of controlling cell growth, osteosarcoma ROS 17/2.8 cells were cultured on chemically modified single-walled (SW) and multiwalled (MW) CNTs. CNTs carrying neutral electric charge sustained the highest cell growth and production of plate-shaped crystals. There was a dramatic change in cell morphology in osteoblasts cultured on MWNTs, which correlated with changes in plasma membrane functions.