Proteomic Analysis of the Human Anterior Pituitary Gland.

Proteomic Analysis of the Human Anterior Pituitary Gland.
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DOI：
10.1089/omi.2018.0160
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发表时间：
2018-12
期刊：
Omics : a journal of integrative biology
影响因子：
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通讯作者：
S. Yelamanchi;Ankur Tyagi;Varshasnata Mohanty;P. Dutta;M. Korbonits;S. Chavan;Jayshree Advani;Anil K. Madugundu;Gourav Dey;K. Datta;M. Rajyalakshmi;Nandini A. Sahasrabuddhe;A. Chaturvedi;Amit Kumar;A. A. Das-A.;Dhiman Ghosh;Gajendra M Jogdand;Haritha H. Nair;K. Saini;M. Panchal;Mansi Ashwinsinh Sarvaiya;S. S. Mohanraj-S.;Nabonita Sengupta;Priti Saxena;P. A. Subramani;Pradeep Kumar;Rakhil Akkali;S. Reshma;R. Santhosh;S. Rastogi;Sudarshan Kumar;S. Ghosh;V. K. Irlapati;A. Srinivasan;B. Radotra;P. Mathur;G. W. Wong;P. Satishchandra;Aditi Chatterjee;H. Gowda;A. Bhansali;A. Pandey;S. Shankar;A. Mahadevan;T. Prasad
S. Yelamanchi;Ankur Tyagi;Varshasnata Mohanty;P. Dutta;M. Korbonits;S. Chavan;Jayshree Advani;Anil K. Madugundu;Gourav Dey;K. Datta;M. Rajyalakshmi;Nandini A. Sahasrabuddhe;A. Chaturvedi;Amit Kumar;A. A. Das-A.;Dhiman Ghosh;Gajendra M Jogdand;Haritha H. Nair;K. Saini;M. Panchal;Mansi Ashwinsinh Sarvaiya;S. S. Mohanraj-S.;Nabonita Sengupta;Priti Saxena;P. A. Subramani;Pradeep Kumar;Rakhil Akkali;S. Reshma;R. Santhosh;S. Rastogi;Sudarshan Kumar;S. Ghosh;V. K. Irlapati;A. Srinivasan;B. Radotra;P. Mathur;G. W. Wong;P. Satishchandra;Aditi Chatterjee;H. Gowda;A. Bhansali;A. Pandey;S. Shankar;A. Mahadevan;T. Prasad
中科院分区：
其他
文献类型：
--
作者：
S. Yelamanchi;Ankur Tyagi;Varshasnata Mohanty;P. Dutta;M. Korbonits;S. Chavan;Jayshree Advani;Anil K. Madugundu;Gourav Dey;K. Datta;M. Rajyalakshmi;Nandini A. Sahasrabuddhe;A. Chaturvedi;Amit Kumar;A. A. Das-A.;Dhiman Ghosh;Gajendra M Jogdand;Haritha H. Nair;K. Saini;M. Panchal;Mansi Ashwinsinh Sarvaiya;S. S. Mohanraj-S.;Nabonita Sengupta;Priti Saxena;P. A. Subramani;Pradeep Kumar;Rakhil Akkali;S. Reshma;R. Santhosh;S. Rastogi;Sudarshan Kumar;S. Ghosh;V. K. Irlapati;A. Srinivasan;B. Radotra;P. Mathur;G. W. Wong;P. Satishchandra;Aditi Chatterjee;H. Gowda;A. Bhansali;A. Pandey;S. Shankar;A. Mahadevan;T. Prasad

文献摘要

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The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.