Human uterine natural killer cells: a reappraisal
Human uterine natural killer cells: a reappraisal
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DOI：
10.1016/j.molimm.2004.07.035
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发表时间：
2005-02-01
影响因子：
3.6
通讯作者：
Lash, GE
中科院分区：
文献类型：
--
作者：
Bulmer, JN;Lash, GE
许多物种子宫内颗粒细胞的存在已被识别多年，但直到最近才被识别为NK细胞的一种。不同的术语被应用于这些细胞，包括子宫内膜粒细胞、K细胞，以及小鼠和大鼠的子宫内膜腺颗粒细胞。虽然早期的研究通常是基于组织学和电子显微镜，但这些通常包括对当前研究的重要信息。纯化细胞的体外研究主要集中在细胞毒性和细胞因子的产生，以及在人类妊娠中滋养细胞侵袭和螺旋动脉重塑的控制中的作用。小鼠的证据表明，uNK细胞在血管重构中产生ifn - γ，但对人类uNK细胞的这种作用的证据仍有待建立。由于缺乏血管重构发生的妊娠中期前半期的组织，以及来自蜕膜不同区域的细胞之间可能存在的差异，阻碍了对人类妊娠期uNK细胞的研究。在没有滋养细胞侵入子宫和上皮胎盘的物种中存在类似的细胞，这提出了一个问题，即人类uNK细胞对滋养细胞入侵的控制在体内是否重要，并提出了在物种之间保守的另一种功能的可能性。(C) 2004 Elsevier Ltd.版权所有。
The presence of granulated cells within the uterus of many species has been recognised for many years but only recently have these been recognised to be a type of NK cell. Various terms have been applied to the cells, including endometrial granulocyte, K cell and, in mouse and rat, granulated metrial gland cell. Although early studies are often based on histology and electron microscopy, these often include important information for current studies. In vitro studies of purified cells have focused particularly on cytotoxicity and cytokine production and roles in the control of trophoblast invasion and spiral artery remodelling in human pregnancy have been proposed. Evidence in mouse has implicated uNK cell production of IFN-gamma in vascular remodelling but evidence for such a role for human uNK cells remains to be established. Investigation of uNK cells in human pregnancy is hampered by the lack of availability of tissues from the first half of the second trimester of pregnancy when vascular remodelling occurs and also by possible differences between cells from different regions of decidua. The presence of similar cells in species with no trophoblast invasion into the uterus and epitheliochorial placentation raises the question of whether control of trophoblast invasion by human uNK cells is important in vivo and raises the possibility of another function which is conserved between species. (C) 2004 Elsevier Ltd. All rights reserved.