Relationship of visit-to-visit and ambulatory blood pressure variability to vascular function in African Americans.
Relationship of visit-to-visit and ambulatory blood pressure variability to vascular function in African Americans.
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DOI：
10.1038/hr.2011.135
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发表时间：
2012-01
影响因子：
5.4
通讯作者：
Brown, Michael D.
中科院分区：
文献类型：
--
作者：
Diaz, Keith M.;Veerabhadrappa, Praveen;Kashem, Mohammed A.;Feairheller, Deborah L.;Sturgeon, Kathleen M.;Williamson, Sheara T.;Crabbe, Deborah L.;Brown, Michael D.
关键词：
访视间门诊血压变异性（BPV）和24小时BPV均被确定为心血管（CV）发病率和死亡率的独立风险因素;然而，导致CV风险增加的机制尚不清楚。本研究的目的是在一组健康的非裔美国人中评估BPV和内皮功能之间的关系。36名久坐不动、非糖尿病、不吸烟、无心血管和肾脏疾病且未服用抗高血压药物的非裔美国人遵循美国心脏协会低脂肪、低盐饮食6周。在完成6周的饮食稳定期后，参与者进行了24小时动态血压监测，并在三个不同的日子测量了他们的办公室血压。在静息、反应性充血期间（血流介导的扩张：FMD）和硝酸甘油给药后（硝酸甘油介导的扩张：NMD）评估右肱动脉直径。与内皮功能正常的受试者相比，根据%FMD或FMD/NMD比值分类为内皮功能降低的受试者的24小时BPV显著更高，访视间BPV有更高的趋势。连续变量分析显示NMD和24小时舒张期BPV（DBPV）之间存在显著正相关。访视间收缩压BPV（SBPV）、24小时SBPV和24小时DBPV均与FMD/NMD比值呈负相关。在校正年龄、BMI和平均BP水平后，所有关系仍然显著。这些结果可能表明，BPV是在非洲裔美国人的内皮功能下降，并与血管平滑肌对一氧化氮的反应。
Visit-to-visit clinic blood pressure variability (BPV) and 24-hour BPV have both been identified as independent risk factors for cardiovascular (CV) morbidity and mortality; however the mechanisms contributing to the increased CV risk as yet are unclear. The purpose of this study was to assess the relationship between BPV and endothelial function in a cohort of putatively healthy African Americans. 36 African Americans who were sedentary, non-diabetic, non-smoking, free of cardiovascular and renal disease and not on antihypertensive medication followed an American Heart Association low fat, low salt diet for 6 weeks. Upon completion of the 6-week dietary stabilization period, participants underwent 24-hour ambulatory BP monitoring and had their office BP measured on three separate days. Right brachial artery diameter was assessed at rest, during reactive hyperemia (flow-mediated dilation: FMD), and after nitroglycerin administration (nitroglycerin-mediated dilation: NMD). Participants classified as having decreased endothelial function according to either %FMD or the FMD/NMD ratio had significantly higher 24-hour BPV and a trend for higher visit-to-visit BPV when compared to participants with normal endothelial function. Continuous variable analyses revealed a significant positive association between NMD and 24-hour diastolic BPV (DBPV). Visit-to-visit systolic BPV (SBPV), 24-hour SBPV, and 24-hour DBPV were all negatively associated with the FMD/NMD ratio. All relationships remained significant after adjustment for age, BMI, and mean BP levels. These results may suggest that BPV is in increased in African Americans with decreased endothelial function and is associated with the vascular smooth muscle response to nitric oxide.
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影响因子：
3.4
作者：
CHRIST, GJ;BRINK, PR;RAMANAN, SV
通讯作者：
RAMANAN, SV
DOI：
10.1016/s0735-1097(03)00927-6
发表时间：
2003-09-17
影响因子：
24
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影响因子：
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作者：
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通讯作者：
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影响因子：
37.8
作者：
Lind, Lars;Berglund, Lars;Sundstrom, Johan
通讯作者：
Sundstrom, Johan