CD8(+) T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite.
CD8(+) T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite.
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DOI：
10.1016/j.micinf.2016.03.013
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发表时间：
2016-07
影响因子：
5.8
通讯作者：
Suzuki Y
中科院分区：
文献类型：
--
作者：
Ochiai E;Sa Q;Perkins S;Grigg ME;Suzuki Y
Our previous study demonstrated that CD8+ T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8+ immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8+ T cells removed cysts of a type III strain. Therefore, CD8+ T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.
