ATTENTION AND SCHIZOPHRENIA - IMPAIRED MODULATION OF THE STARTLE REFLEX
ATTENTION AND SCHIZOPHRENIA - IMPAIRED MODULATION OF THE STARTLE REFLEX
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DOI：
10.1037/0021-843x.102.4.633
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发表时间：
1993-11-01
影响因子：
4.6
通讯作者：
SCHELL, AM
中科院分区：
文献类型：
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作者：
DAWSON, ME;HAZLETT, EA;SCHELL, AM
由突然刺激引起的惊吓反射（SR）可以通过注意在惊吓诱发刺激之前不久的非惊吓刺激来修改。本研究的15个最近发病的，相对无症状的精神分裂症门诊患者和14个人口统计学匹配的正常对照组表明，注意调制的SR精神分裂症患者受损。具体而言，对照组表现出更大的惊吓眨眼修改后，被关注的prestimuli比被忽略的prestimuli，而患者未能显示注意调制效果。这些结果表明，精神分裂症患者的注意力缺陷特征，因为病人是相对无症状的。SR的注意调制的测量可能提供了一个非语言的，反射性的，独立于状态的精神分裂症的易感性标记。
The startle reflex (SR) elicited by abrupt stimuli can be modified by attention to nonstartling stimuli that shortly precede the startle-eliciting stimulus. The present study of 15 recent-onset, relatively asymptomatic schizophrenic outpatients and 14 demographically matched normal control subjects demonstrated that attentional modulation of SR is impaired in schizophrenic patients. Specifically, the control group exhibited greater startle eye-blink modification following to-be-attended prestimuli than following to-be-ignored prestimuli, whereas the patients failed to show the attentional modulation effect. These results suggest traitlike attentional deficits in schizophrenia because the patients were relatively asymptomatic. The measurement of attentional modulation of SR may provide a nonverbal, reflexive, state-independent marker of the vulnerability to schizophrenia.