Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine.
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine.
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隐藏在众目睽睽之下：基于表位的亚单位疟疾疫苗策略。
DOI：
10.1016/j.pt.2023.08.006
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发表时间：
2023
影响因子：
9.6
通讯作者：
Yanow,StephanieK
中科院分区：
文献类型：
--
作者：
Good,MichaelF;Yanow,StephanieK
最近的数据表明，开发亚单位血液期疟疾疫苗的方法可能是错误的。虽然抗原多态被认为是一种挑战，但应对这一挑战的努力主要包括用强大的佐剂提高抗体的数量和质量，识别保守的靶蛋白，或结合多种抗原来扩大免疫反应。然而，矛盾的是，有证据表明，免疫反应可能需要缩小而不是扩大，以获得保护多种疟原虫株的免疫反应。非免疫优势、保守的表位至关重要。证据来自于对红细胞表面表达抗原的免疫反应的研究，但也应该适用于裂殖子表面抗原。提供了定义这些高度集中的免疫反应的目标的策略。
Recent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain an immune response protective against multiplePlasmodiumstrains. Non-immunodominant, conserved epitopes are crucial. The evidence comes from studying the immune response to red cell surface-expressed antigens but should also be applicable to merozoite surface antigens. Strategies to define the targets of these highly focused immune responses are provided.