Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats
Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats
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DOI：
10.1002/syn.10242
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发表时间：
2003-10-01
期刊：
影响因子：
2.3
通讯作者：
Markou, A
中科院分区：
文献类型：
--
作者：
Bruijnzeel, AW;Markou, A
安非他酮是一种非典型的抗抑郁药物，是美国食品和药物管理局批准用于戒烟的唯一非尼古丁类处方药。本实验的目的是研究安非他酮（5-40 mg/kg）对大鼠尼古丁和食物强化特性的影响。安非他酮的影响进行了研究，在两个时间表的强化：固定比例5超时20秒（FR 5 TO 20秒）和渐进的比例（PR）。根据FR 5 TO 20 s时间表，训练大鼠对尼古丁（0.01或0.03 mg/kg/输注，游离碱）或食物产生反应。最高剂量安非他酮（40 mg/kg）预处理导致大鼠自我给予0.03 mg/kg/输注尼古丁后尼古丁摄入量显著降低（接近50%）。相同剂量的安非他酮也使0.01 mg/kg/输注尼古丁的自我给药减少（相似于40%），但该效应未达到统计学显著性。安非他酮预处理轻微（类似于15%）降低了FR 5 TO 20 s时间表下的食物反应。最后，安非他酮预处理不影响PR时间表下尼古丁（0.03 mg/kg/输注）的自我给药，但在相同PR时间表下，剂量依赖性增加对食物的反应。这些发现表明，高剂量的安非他酮降低了根据FR时间表测量的尼古丁的增强特性，而在反映增强特性和获得尼古丁的动机的PR时间表下，对尼古丁的断裂点没有明显影响。(C)2003 Wiley-Liss，Inc.
Bupropion is an atypical antidepressant drug that is the only nonnicotine-based prescription medicine approved for smoking cessation by the Food and Drug Administration. The aim of the present experiments was to investigate the effects of bupropion (5-40 mg/kg) on the reinforcing properties of nicotine and food in rats. The effects of bupropion were studied under two schedules of reinforcement: a fixed ratio 5 time-out 20-sec (FR5 TO20 s) and a progressive ratio (PR). Rats were trained to respond for nicotine (0.01 or 0.03 mg/kg/infusion, free base) or food under the FR5 TO20 s schedule. Pretreatment with the highest dose of bupropion (40 mg/kg) resulted in a significant reduction (similar to50%) of nicotine intake in rats self-administering 0.03 mg/kg/ infusion of nicotine. The same dose of bupropion also decreased (similar to40%) the self-administration of 0.01 mg/kg/infusion of nicotine, but this effect did not reach statistical significance. Pretreatment with bupropion slightly (similar to15%) reduced responding for food under the FR5 TO20 s schedule. Finally, pretreatment with bupropion did not affect the self-administration of nicotine (0.03 mg/kg/infusion) under a PR schedule, but dose-dependently increased responding for food under the same PR schedule. These findings indicate that a high dose of bupropion decreases the reinforcing properties of nicotine as measured under an FR schedule, while having no apparent effects on breaking points for nicotine under a PR schedule that reflects both the reinforcing properties and the motivation to obtain nicotine. (C) 2003 Wiley-Liss, Inc.