Association of genetic variants in the CART gene with glioma susceptibility in a Chinese population
Association of genetic variants in the CART gene with glioma susceptibility in a Chinese population
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DOI：
10.18632/oncotarget.11763
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Liang Wang;Gang Li;Nan Liu;Zhen Wang;Xiaoshan Xu;Jing Qi;Dongni Ren;Pengxing Zhang;Yongsheng Zhang;Y. Tu
中科院分区：
文献类型：
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作者：
Liang Wang;Gang Li;Nan Liu;Zhen Wang;Xiaoshan Xu;Jing Qi;Dongni Ren;Pengxing Zhang;Yongsheng Zhang;Y. Tu
// 王亮 1,* , 李刚 1,* , 刘楠 2,* , 王振 2 , 徐晓山 2 , 齐静 2 , 任冬妮 2 , 张鹏星 2 , 张永胜 3 和涂艳阳 2 1 第四军医大学唐都医院神经外科，中国西安 2 第四军医大学唐都医院实验外科 中国西安医科大学 3 中国西安第四军医大学唐都医院行政部 * 这些作者对本文有同等贡献通讯作者：Yanyang Tu，电子邮件：// Yongsheng Zhang，电子邮件：// 关键词：CART；神经胶质瘤；多态性；遗传易感性 收稿日期：2016 年 6 月 29 日 接受日期：2016 年 8 月 26 日 发布日期：2016 年 8 月 31 日 摘要 胶质瘤是一种罕见且高度致命的脑癌，人们对其进行了数十年的研究。然而，仅确定了少数病因。遗传因素在神经胶质瘤的发展中起着重要作用，也是预防性肿瘤学的关键组成部分。然而，只有一小部分遗传效应尚未确定。在当前的研究中，我们通过两阶段病例对照研究，系统地评估了 CART 基因的遗传变异是否会导致中国人患胶质瘤的易感性，该基因会产生多种生物活性肽。在第一阶段，我们发现rs2239670（等位基因A vs G：OR = 1.33；95% CI = 1.03-1.70；P = 0.026）和rs11575893（等位基因T vs C：OR = 1.29；95% CI = 1.01-1.65；P = 0.040）与神经胶质瘤增加显着相关易感性。然后这两个 SNP 在独立阶段显着复制。当汇总在一起时，rs2239670（等位基因 A vs G：OR = 1.27；95% CI = 1.10-1.46；P = 0.001）和 rs11575893（等位基因 T vs C：OR = 1.25；95% CI = 1.09-1.45；P = 0.002）与神经胶质瘤增加显着相关易感性。我们的数据表明，CART 基因的遗传变异可能使其携带者易患神经胶质瘤。
// Liang Wang 1,* , Gang Li 1,* , Nan Liu 2,* , Zhen Wang 2 , Xiaoshan Xu 2 , Jing Qi 2 , Dongni Ren 2 , Pengxing Zhang 2 , Yongsheng Zhang 3 and Yanyang Tu 2 1 Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China 2 Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China 3 Department of Administrative, Tangdu Hospital, Fourth Military Medical University, Xi’an, China * These authors have contributed equally to this article Correspondence to: Yanyang Tu, email: // Yongsheng Zhang, email: // Keywords : CART; gliomas; polymorphism; genetic susceptibility Received : June 29, 2016 Accepted : August 26, 2016 Published : August 31, 2016 Abstract Glioma, which is a rare and highly fatal brain cancer, has been studied for many decades. However, only a few etiological factors have been established. Genetic factors play an essential roles in the development of gliomas and are key component of preventive oncology. However, only a small proportion of the genetic effect has been yet established. In current study, we systematically evaluated whether genetic variants of CART gene, which generates multiple biologically active peptides, contribute to susceptibility of gliomas among Chinese people with a two-stage, case–control study. In stage I, we found rs2239670 (Allele A vs G: OR = 1.33; 95% CI = 1.03-1.70; P = 0.026) and rs11575893 (Allele T vs C: OR = 1.29; 95% CI = 1.01-1.65; P = 0.040) were significantly associated with increased glioma susceptibility. Then the two SNPs were significantly replicated in an independent stage. When pooled together, both rs2239670 (Allele A vs G: OR = 1.27; 95% CI = 1.10-1.46; P = 0.001) and rs11575893 (Allele T vs C: OR = 1.25; 95% CI = 1.09-1.45; P = 0.002) were significant associated with increased glioma susceptibility. Our data suggest that the genetic variants in the CART gene potentially predispose their carriers to gliomas.