Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools
Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools
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DOI：
10.1016/j.jad.2015.10.059
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发表时间：
2016-01-15
影响因子：
6.6
通讯作者：
Miskowiak, Kamilla W.
中科院分区：
文献类型：
--
作者：
Ott, Caroline Vintergaard;Bjertrup, Anne Juul;Miskowiak, Kamilla W.
背景：单相抑郁(UD)患者的持续性认知功能障碍会导致社会职业损害，但目前还没有可行的方法来筛查和监测这类患者的认知功能障碍。本研究探讨了两种新的UD认知功能障碍筛查工具的有效性及其与社会职业能力的关系。方法：使用两种新的筛查工具--精神病学认知障碍筛查丹麦语译本(SCIP-D)和双相情感障碍认知抱怨评定量表(COBRA)以及已建立的神经心理和自我评估工具对53名部分或完全缓解的UD患者和103名健康对照进行评估。结果：SCIP-D量表和COBRA量表分别对客观和主观认知功能障碍有较好的检测效果。三种平行的SCIP-D形式是等价的。SCIP-D-COBRA联合测量对客观认知障碍的敏感性和特异性分别为91%和70%。主观和客观的认知测量之间没有相关性。主观认知障碍与社会-职业损害的相关性更强(r=0.7，p<；0.01)，而客观认知困难与执行技能领域的相关性较弱(r=03，p=0.05)。限制：样本量适中。结论：SCIP-D和COBRA分别是客观和主观认知障碍的有效测量工具，应该在UD认知功能障碍的筛查中联合使用。(C)2015爱思唯尔B.V.保留所有权利。
Background: Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity.Method: Participants (n=53) with UD in partial or full remission and healthy control persons (n=103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively.Results: The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment (r=0.7, p < 0.01) than did objective cognitive difficulties, for which there was a weak correlation with the executive skills domain only (r = 03, p=0.05).Limitations: A modest sample size.Conclusions: The SCIP-D and COBRA are valid measures of objective and subjective cognitive impairment, respectively, and should ideally be implemented together in the screening for cognitive dysfunction in UD. (C) 2015 Elsevier B.V. All rights reserved.