Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters.
Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters.
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DOI：
10.1016/s1672-0229(06)60010-7
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发表时间：
2006-02
影响因子：
9.5
通讯作者：
Yamaguchi-Iwai, Yuko
中科院分区：
文献类型：
--
作者：
Kambe, Taiho;Suzuki, Tomoyuki;Nagao, Masaya;Yamaguchi-Iwai, Yuko
ZIP（ZRT/IRT样蛋白）和CDF（阳离子扩散促进剂）是两个大的金属转运蛋白家族，主要将锌转运进出细胞质。几个ZIP和CDF转运蛋白已在哺乳动物和各种模式生物，如酵母，线虫，果蝇和斑马鱼，和许多候选基因已被确定的基因组计划。最近在一些模式生物中报道了ZIP和CDF转运蛋白的意想不到的功能，从而使我们对哺乳动物对应物的功能的理解取得了重大进展。在这里，我们回顾了最近的信息，真核生物的ZIP和CDF转运蛋白之间的序列相似性和功能的关系，从代表性的模式生物。
ZIP (ZRT/IRT-like Protein) and CDF (Cation Diffusion Facilitator) are two large metal transporter families mainly transporting zinc into and out of the cytosol. Several ZIP and CDF transporters have been characterized in mammals and various model organisms, such as yeast, nematode, fruit fly, and zebrafish, and many candidate genes have been identified by genome projects. Unexpected functions of ZIP and CDF transporters have been recently reported in some model organisms, leading to major advances in our understanding of the functions of mammalian counterparts. Here, we review the recent information on the sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters obtained from the representative model organisms.