Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae
Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae
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DOI：
10.1128/iai.72.4.2434-2437.2004
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发表时间：
2004-04-01
影响因子：
3.1
通讯作者：
Trombe, MC
中科院分区：
文献类型：
--
作者：
Echenique, J;Kadioglu, A;Trombe, MC
在肺炎链球菌基因组中，编码膜相关丝氨酸/苏氨酸激酶的stkP并不是多余的(L. Novakova， S. Romao， J. Echenique， P. Branny, and m . c。Trombe，未发表的结果)。本文的数据表明，StkP属于体外能力触发和体内肺部感染和血流侵袭的信号网络。在能力方面，功能性StkP是激活comCDE上游由能力刺激肽协调的自调节环所必需的。这是首次描述comCDE转录的正调控与CiaRH的抑制平衡。
In the Streptococcus pneumoniae genome, stkP, encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of comCDE upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of comCDE transcription in balance with its repression by CiaRH.