Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.
Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.
复制标题
间隙连接和半通道：神经发育和疾病中的细胞死亡。
DOI：
10.1186/s12860-016-0120-x
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发表时间：
2017-01-17
期刊：
影响因子：
--
通讯作者：
Naus CC
中科院分区：
文献类型：
--
作者：
Belousov AB;Fontes JD;Freitas-Andrade M;Naus CC
缝隙连接是一种独特的膜通道，在发育和成熟的中枢神经系统(CNS)的细胞间通讯中发挥着重要作用。这些通道由连接蛋白蛋白组成，这些连接蛋白寡聚成六聚体形成连接蛋白或半连接蛋白。许多不同的连接蛋白在中枢神经系统中表达，在不同的细胞类型中发现不同的连接蛋白，以及它们在发育和成熟的中枢神经系统中表达的时间点具有一定的特异性。主要的神经元Cx36和神经胶质细胞Cx43在神经发育过程中都发挥着重要作用。这些连接蛋白还调节中枢神经系统对病理条件的不同方面的反应。连接蛋白的表达、翻译、运输和周转的不平衡，以及连接蛋白的突变，都会在神经发育和疾病的细胞死亡的背景下影响它们的功能。随着对大脑中连接蛋白的了解不断加深，可以开发出针对各种神经疾病的这些膜通道的治疗策略。
Gap junctions are unique membrane channels that play a significant role in intercellular communication in the developing and mature central nervous system (CNS). These channels are composed of connexin proteins that oligomerize into hexamers to form connexons or hemichannels. Many different connexins are expressed in the CNS, with some specificity with regard to the cell types in which distinct connexins are found, as well as the timepoints when they are expressed in the developing and mature CNS. Both the main neuronal Cx36 and glial Cx43 play critical roles in neurodevelopment. These connexins also mediate distinct aspects of the CNS response to pathological conditions. An imbalance in the expression, translation, trafficking and turnover of connexins, as well as mutations of connexins, can impact their function in the context of cell death in neurodevelopment and disease. With the ever-increasing understanding of connexins in the brain, therapeutic strategies could be developed to target these membrane channels in various neurological disorders.