Chondroitin sulfate-E mediates estrogen-induced osteoanabolism.
Chondroitin sulfate-E mediates estrogen-induced osteoanabolism.
复制标题
软骨素硫酸盐介导雌激素诱导的骨代谢。
DOI：
10.1038/srep08994
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发表时间：
2015-03-11
影响因子：
4.6
通讯作者：
Kitagawa H
中科院分区：
文献类型：
--
作者：
Koike T;Mikami T;Shida M;Habuchi O;Kitagawa H
Osteoporosis is an age-related disorder of bone remodeling in which bone resorption outstrips bone matrix deposition. Although anticatabolic agents are frequently used as first-line therapies for osteoporosis, alternative anabolic strategies that can enhance anabolic, osteogenic potential are actively sought. Sex steroid hormones, particularly estrogens, are bidirectional regulators for bone homeostasis; therefore, estrogen-mediated events are important potential targets for such anabolic therapies. Here, we show that estrogen-induced, osteoanabolic effects were mediated via enhanced production of chondroitin sulfate-E (CS-E), which could act as an osteogenic stimulant in our cell-based system. Conversely, estrogen deficiency caused reduced expression of CS-E-synthesizing enzymes, including GalNAc4S-6ST, and led to decreased CS-E production in cultures of bone marrow cells derived from ovariectomized mice. Moreover, Galnac4s6st-deficient mice had abnormally low bone mass that resulted from impaired osteoblast differentiation. These results indicated that strategies aimed at boosting CS-E biosynthesis are promising alternative therapies for osteoporosis.
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影响因子：
4.6
作者：
Izumikawa T;Sato B;Kitagawa H
通讯作者：
Kitagawa H
影响因子：
6.2
作者：
Cheng, SL;Shin, CS;Civitelli, R
通讯作者：
Civitelli, R
影响因子：
4.8
作者：
Izumikawa, Tomomi;Koike, Toshiyasu;Kitagawa, Hiroshi
通讯作者：
Kitagawa, Hiroshi
影响因子：
64.8
作者：
Mizuguchi, S;Uyama, T;Nomura, K
通讯作者：
Nomura, K
影响因子：
4.8
作者：
Ohtake-Niimi, Shiori;Kondo, Sachiko;Habuchi, Osami
通讯作者：
Habuchi, Osami