Azidoproline containing helices:: Stabilization of the polyproline II structure by a functionalizable group
Azidoproline containing helices:: Stabilization of the polyproline II structure by a functionalizable group
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DOI：
10.1021/ja067148o
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发表时间：
2007-01-24
影响因子：
15
通讯作者：
Wennemers, Helma
中科院分区：
文献类型：
--
作者：
Kuemin, Michael;Sonntag, Louis-Sebastian;Wennemers, Helma
研究了含4-叠氮脯氨酸的聚脯氨酸的构象和功能化。构象分析表明，PPII螺旋被（4 R）Azp稳定，被（4S）Azp去稳定。含Azp的聚脯氨酸的功能化通过“点击化学”以差异方式有效地完成，使得含Azp的聚脯氨酸具有吸引力的分子支架。
The conformation and functionalizability of 4-azidoproline containing polyprolines was studied. The conformational analyses demonstrate that the PPII helix is stabilized by (4R)Azp and destabilized by (4S)Azp. Functionalization of Azp containing polyprolines was accomplished efficiently in a differential fashion by "click chemistry", rendering Azp containing polyprolines attractive molecular scaffolds.