Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000
Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000
复制标题
DOI：
10.1038/nprot.2016.001
复制
发表时间：
2016-01-01
期刊：
影响因子：
14.8
通讯作者：
Farha, Omar K.
中科院分区：
文献类型：
--
作者：
Wang, Timothy C.;Vermeulen, Nicolaas A.;Farha, Omar K.
NUU-1000是一种高度稳健的中孔（含有> 2nm的孔）金属有机框架（MOF），其合成可以从廉价的起始材料以数克规模有效地进行。四溴芘和（4-（乙氧羰基）苯基）硼酸可以很容易地偶联，以制备所需的有机支柱与四个金属结合位点的四个羧酸的形式，而氧氯化锆八水合物被用作前体的定义明确的金属氧化物簇。NUU-1000已被报道为气体分离的优秀候选物，并且它是多相催化的多功能支架。特别是，它是理想的催化灭活神经毒剂，它显示了巨大的希望作为一个新的通用平台，广泛的应用。使用NUU-1000作为母体材料开发了多种合成后修饰方案，使其成为几种催化应用的潜在有用支架。用于制备NUU-1000的程序可以可靠地按比例放大，并且其适合于生产50 g含有机连接剂的四羧酸和200 mg-2.5 g NUU-1000。整个合成过程不经柱层析纯化，可在10 d内完成。
The synthesis of NUNU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl) phenyl) boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NUNU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NUNU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NUNU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NUNU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.