Online Artifact Cancelation in Same-Electrode Neural Stimulation and Recording Using a Combined Hardware and Software Architecture.
Online Artifact Cancelation in Same-Electrode Neural Stimulation and Recording Using a Combined Hardware and Software Architecture.
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DOI：
10.1109/tbcas.2018.2816464
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发表时间：
2018-06
影响因子：
5.1
通讯作者：
Liu W
中科院分区：
文献类型：
--
作者：
Culaclii S;Kim B;Lo YK;Li L;Liu W
推进神经网络动力学的研究和闭环神经接口的开发需要同时刺激和记录神经细胞的能力。邻近刺激部位或在刺激部位处的记录产生比感兴趣的神经响应大几个数量级的伪影信号。这些信号通常会使记录放大器饱和，导致短潜伏期诱发反应失真或丢失。本文提出了一种在同一电极上同时记录和刺激神经信号时消除伪影的方法。通过结合一种新的硬件架构与并发的软件处理，该设计实现了在广泛的条件下的神经信号恢复。所提出的系统独特地展示了相同电极刺激和记录，在存在比潜在信号大100 dB的刺激伪影的情况下神经信号恢复。在同一电极上同时刺激和记录期间，对系统进行体外和体内测试。将啮齿动物模型中的体内结果与由并联连接的商业神经放大器系统进行的记录进行比较。
Advancing studies of neural network dynamics and developments of closed-loop neural interfaces requires the ability to simultaneously stimulate and record the neural cells. Recording adjacent to or at the stimulation site produces artifact signals that are orders of magnitude larger than the neural responses of interest. These signals often saturate the recording amplifier causing distortion or loss of short-latency evoked responses. This paper proposes a method to cancel the artifact in simultaneous neural recording and stimulation on the same electrode. By combining a novel hardware architecture with concurrent software processing the design achieves neural signal recovery in a wide range of conditions. The proposed system uniquely demonstrates same-electrode stimulation and recording, with neural signal recovery in presence of stimulation artifact 100dB larger in magnitude than the underlying signals. The system is tested both in vitro and in vivo, during concurrent stimulation and recording on the same electrode. In-vivo results in a rodent model are compared to recordings made by a commercial neural amplifier system connected in parallel.