Delineating the "galectin signature" of the tumor microenvironment.
Delineating the "galectin signature" of the tumor microenvironment.
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DOI：
10.4161/onci.23565
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发表时间：
2013-04-01
期刊：
影响因子：
7.2
通讯作者：
Rabinovich GA
中科院分区：
文献类型：
--
作者：
Compagno D;Laderach DJ;Gentilini L;Jaworski FM;Rabinovich GA
Galectins是一个糖链结合蛋白家族，可以通过促进转化、血管生成和免疫逃逸来控制肿瘤的进展。我们发现了一个动态调节的‘Galectin Signature’，它描绘了前列腺癌的进展，突出了Galectin-1是疾病晚期抗血管生成治疗的一个有吸引力的靶点。
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated ‘galectin signature’, which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.