PADI4 polymorphisms and rheumatoid arthritis susceptibility:: a meta-analysis
PADI4 polymorphisms and rheumatoid arthritis susceptibility:: a meta-analysis
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DOI：
10.1007/s00296-007-0320-y
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发表时间：
2007-07-01
影响因子：
4
通讯作者：
Song, Gwan Gyu
中科院分区：
文献类型：
--
作者：
Lee, Young Ho;Rho, Young Hee;Song, Gwan Gyu
我们对肽基精氨酸脱亚胺酶4（PADI 4）多态性的等位基因和基因型与RA总体和各种族人群的相关性进行了全面的荟萃分析，以探讨PADI 4多态性是否赋予RA的易感性。这项荟萃分析包括来自8项研究的9项比较，3名亚洲人和6名欧洲人。总体荟萃分析显示，PADI 4_94、104和90与RA显著相关（OR分别为1.20、1.17、1.35，P = 0.001、< 0.0001、0.006）。在亚裔人群中，所有PADI 4多态性与RA有显著相关性。然而，在欧洲血统的人中，除了PADI_94之外，PADI 4多态性与RA没有显著关联。PADI 4 2/2基因型的存在显着增加了欧洲人群患RA的风险（OR = 2.10，95%CI，1.66-2.66，P < 0.0001），且研究间不存在异质性（I-2 = 44.3，P = 0.15）。总之，这项荟萃分析表明，PADI 4多态性可能是亚洲人和欧洲人RA的一个重要危险因素，并且在亚洲人群对RA的易感性方面可能比欧洲人群发挥更大的作用。还需要进一步的研究来确定PADI 4基因是否会在其他种族群体中赋予患RA的风险。
We conducted a comprehensive meta-analysis with all available data on the association of allele and genotype of peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall and in each ethnic population to explore whether the PADI4 polymorphisms confer susceptibility to RA. Nine comparisons, three Asians and six Europeans, from eight studies were included in this meta-analysis. Overall meta-analysis shows a significant association of PADI4_94, 104 and 90 with RA (OR = 1.20, 1.17, 1.35, P = 0.001, < 0.0001, 0.006, respectively). There was a significant association with all of the PADI4 polymorphisms with RA in people of Asian descent. However, there was no significant association of PADI4 polymorphisms with RA in people of European descent, except for PADI_94. The presence of 2/2 genotype of the PADI4 significantly increased the risk for RA in European populations (OR = 2.10, 95% CI, 1.66-2.66, P < 0.0001) without between-study heterogeneity (I-2 = 44.3, P = 0.15). In conclusion, this meta-analysis demonstrates that the PADI4 polymorphisms may represent a significant risk factor for RA in Asians and Europeans and may play a larger role in susceptibility to RA in Asian than in European populations. Further studies are needed to see if the PADI4 gene confers a risk of RA in other ethnic groups.