Effects of Lime Juice on Malaria Parasite Clearance
Effects of Lime Juice on Malaria Parasite Clearance
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DOI：
10.1002/ptr.3418
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发表时间：
2011-10-01
影响因子：
7.2
通讯作者：
Adeyemi, L. A.
中科院分区：
文献类型：
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作者：
Adegoke, S. A.;Oyelami, O. A.;Adeyemi, L. A.
120名患有急性无并发症疟疾的儿童在伊利萨卫斯理公会医院（尼日利亚奥逊州伊费岛奥巴费米阿沃洛沃大学教学医院综合体的一个单位）的儿童门诊部接受治疗，他们被招募到研究中，以确定酸橙汁对疟疾寄生虫清除的影响。这些儿童被随机分配到世界卫生组织推荐的抗疟药物（青蒿素联合疗法，ACT）单独或与酸橙汁一起治疗。其中9人失访，4人在ACT和石灰治疗组，5人在ACT单独治疗组，ACT和石灰治疗组达到寄生虫负荷减少>75%的平均（SD）时间显著缩短; 30.5 +/- 2.4小时，而单独ACT组为38.6 +/- 3.3小时（p < 0.001）。此外，虽然抗疟药物和石灰汁的儿童在治疗72小时内达到完全寄生虫清除的比例显著较高（p = 0.007），但10名（18.2%）未使用石灰的患者早期治疗失败（p = 0.003）。使用酸橙汁没有副作用，因此可以推断，从这项初步工作中，酸橙汁与适当的抗疟药一起使用时，可以提高疟疾寄生虫的清除率，特别是在那些没有并发症的疟疾患者中。版权所有（C）2011约翰威利父子有限公司
One hundred and twenty children with acute uncomplicated malaria who were managed at the children's outpatient department of the Wesley Guild Hospital, Ilesa (a unit of Obafemi Awolowo University Teaching Hospitals' Complex, Ile-Ife, Osun state, Nigeria) were recruited into the study to determine the effects of lime juice on malaria parasite clearance. These children were randomized into treatment with World Health Organization recommended antimalarials (artemisinin combination therapy, ACT) either alone or with lime juice. Nine of them were lost to follow-up, four were in the group that were managed with ACT and lime, and five in the group that were managed on ACT alone.The average (SD) time to achieve >75% reduction in parasite load was significantly lower in patients on ACT and lime; 30.5 +/- 2.4 h against 38.6 +/- 3.3 h for those on ACT alone (p < 0.001). Also, while a significantly higher proportion of children on antimalarial drugs and lime juice achieved complete parasite clearance by 72 h of therapy (p = 0.007), ten (18.2%) patients without lime had early treatment failure (p = 0.003). There were no side effects with the use of lime juice.It may therefore be inferred, from this preliminary work, that lime juice when used with the appropriate antimalarial may enhance malaria parasite clearance especially in those with uncomplicated malaria. Copyright (C) 2011 John Wiley & Sons, Ltd.