REDUCTION TO HOMOZYGOSITY OF GENES ON CHROMOSOME-11 IN HUMAN-BREAST NEOPLASIA
REDUCTION TO HOMOZYGOSITY OF GENES ON CHROMOSOME-11 IN HUMAN-BREAST NEOPLASIA
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DOI：
10.1126/science.3659909
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发表时间：
1987-10-09
期刊：
影响因子：
56.9
通讯作者：
CALLAHAN, R
中科院分区：
文献类型：
--
作者：
ALI, IU;LIDEREAU, R;CALLAHAN, R
在人类肿瘤中发生的正常等位基因的杂合性体细胞丢失提示了隐性癌基因的存在。本文结果表明原发性乳腺肿瘤11号染色体上有几个基因的杂合性丢失。这些DNA的限制性片段长度多态性分析进一步表明，乳腺肿瘤中最常见的序列丢失发生在β-珠蛋白和甲状旁腺激素基因座在染色体11的短臂上。染色体11位点的杂合性缺失与缺乏雌激素和孕激素受体的肿瘤、III级肿瘤和远端转移有显著相关性。
The somatic loss of heterozygosity for normal alleles occurring in human tumors has suggested the presence of recessive oncogenes. The results presented here demonstrate a loss of heterozygosity of several genes on chromosome 11 in primary breast tumors. Restriction fragment length polymorphism analysis of these DNAs further suggests that the most frequent loss of sequences in breast tumors occurs between the .beta.-globin and parathyroid hormone loci on the short arm of chromosome 11. The loss of heterozygosity for chromosome 11 loci has a significant association with tumors that lack estrogen and progesterone receptors, grade III tumors, and distal metastasis.