DNA in nanopores: Counterion condensation and coion depletion
DNA in nanopores: Counterion condensation and coion depletion
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DOI：
10.1103/physrevlett.94.148103
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发表时间：
2005-04-15
影响因子：
8.6
通讯作者：
Tanaka, M
中科院分区：
文献类型：
--
作者：
Rabin, Y;Tanaka, M
分子动力学模拟被用来研究一价离子的平衡分布在纳米孔连接两个水库分开的膜，无论是空的孔，并与一个单链DNA分子内。在DNA的存在下，抗衡离子凝聚在拉伸的大分子上，有效地中和它，并观察到几乎完全耗尽孔中的共离子。我们的研究结果对DNA易位通过α-溶血素纳米孔的实验的影响进行了讨论。
Molecular dynamics simulations are used to study the equilibrium distribution of monovalent ions in a nanopore connecting two water reservoirs separated by a membrane, both for the empty pore and that with a single stranded DNA molecule inside. In the presence of DNA, the counterions condense on the stretched macromolecule effectively neutralizing it, and nearly complete depletion of coions from the pore is observed. The implications of our results for experiments on DNA translocation through alpha-hemolysin nanopores are discussed.