Prospective Cardiac MRI for the Analysis of Biventricular Function in Children Undergoing Cancer Treatments
Prospective Cardiac MRI for the Analysis of Biventricular Function in Children Undergoing Cancer Treatments
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DOI：
10.1002/pbc.25381
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发表时间：
2015-05-01
影响因子：
3.2
通讯作者：
Moniotte, Stephane
中科院分区：
文献类型：
--
作者：
de Goyet, Maelle de Ville;Brichard, Benedicte;Moniotte, Stephane
研究背景肿瘤毒性是儿童癌症存活者最严重的长期并发症之一。左心室射血分数和缩短分数的测量仍然是心脏收缩功能障碍的最常见的筛查工具。然而，M型超声心动图可以被视为一种粗糙的方法，因为现在已经有了完善的策略。这项前瞻性研究的目的是确定心脏MRI在检测亚临床左或右心室功能障碍以及在接受癌症治疗的患者中心肌瘢痕形成的患病率中的作用。心脏磁共振成像（cMRI）。结果仅2例患者出现早期左室收缩功能障碍。通过cMRI测量，整个队列的左心房容积显著增加。这一发现与蒽环类药物的总累积剂量相关（r=0.34; P
BackgroundCardiotoxicity is one of the most serious long-term complications in childhood cancer survivors. Measurement of the left ventricular ejection and shortening fraction remains the most common screening tool for cardiac systolic dysfunction. However, M-mode echocardiography can be viewed as a crude approach as refined strategies are now available. The aim of this prospective study was to determine the role of cardiac MRI in the detection of subclinical left or right ventricular dysfunction as well as the prevalence of myocardial scaring in patients undergoing cancer treatments.ProcedureEighty-one children were enrolled in a pre-chemotherapy and then in a yearly protocol including a: (i) clinical evaluation; (ii) laboratory evaluation; (iii) electrocardiogram; (iv) echocardiogram; and (v) a cardiac magnetic resonance imaging (cMRI).ResultsEarly left ventricular systolic dysfunction was only detected in two patients. The entire cohort presented a significant increase of the left atrial volume as measured by cMRI. This finding correlated with the total cumulative dose of anthracyclines (r=0.34; P