A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia
A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia
复制标题
DOI：
10.1242/dev.02678
复制
发表时间：
2006-12-01
期刊：
影响因子：
4.6
通讯作者：
Adams, Richard J.
中科院分区：
文献类型：
--
作者：
England, Samantha J.;Blanchard, Guy B.;Adams, Richard J.
细胞在发育过程中形成和折叠的机制知之甚少。一个例子是在神经形成期间前脑神经板的复杂重组，它必须将一张折叠成一个管，同时从神经板内的单个连续区域外翻两只眼睛。我们，第一次，跟踪这些细胞重排，以表明前脑形态发生显着不同，从先前的假设。我们假设一个新的模型前脑神经元形成，并展示了如何影响两个信号通路的突变可以产生cyclopic表型破坏正常的细胞运动或引入新的错误行为。
Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.