Specification of the germ line.
Specification of the germ line.
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DOI：
10.1895/wormbook.1.9.1
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发表时间：
2005-07-28
期刊：
影响因子：
--
通讯作者：
Strome, Susan
中科院分区：
文献类型：
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作者：
Strome, Susan
In C.在线虫中，在胚胎发生的早期，生殖细胞系与索马分离。几个重要的主题已经出现在指定和指导发展的新生生殖系。在早期阶段，生殖系卵裂球由转录抑制因子PIE-1维持在转录沉默状态。当这种沉默被解除时，假定生殖系基因表达的正确模式至少部分地由染色质状态的MES介导的调节控制。伴随着PIE-1和MES蛋白的转录调节，生殖细胞中的RNA代谢可能受到核周富含RNA的细胞质颗粒（称为P颗粒）的调节。本章讨论了这些不同的生殖细胞调节分子的性质和可能的作用，并描述了最近发现的机制，以保护体细胞从以下生殖细胞的命运。
In C. elegans, the germ line is set apart from the soma early in embryogenesis. Several important themes have emerged in specifying and guiding the development of the nascent germ line. At early stages, the germline blastomeres are maintained in a transcriptionally silent state by the transcriptional repressor PIE-1. When this silencing is lifted, it is postulated that correct patterns of germline gene expression are controlled, at least in part, by MES-mediated regulation of chromatin state. Accompanying transcriptional regulation by PIE-1 and the MES proteins, RNA metabolism in germ cells is likely to be regulated by perinuclear RNA-rich cytoplasmic granules, termed P granules. This chapter discusses the molecular nature and possible roles of these various germline regulators, and describes a recently discovered mechanism to protect somatic cells from following a germline fate.