Isotretinoin ameliorates renal damage in experimental acute renal allograft rejection
Isotretinoin ameliorates renal damage in experimental acute renal allograft rejection
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DOI：
10.1097/01.tp.0000066354.31050.5a
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发表时间：
2003-08-15
期刊：
影响因子：
6.2
通讯作者：
Wagner, J
中科院分区：
文献类型：
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作者：
Kiss, E;Adams, J;Wagner, J
背景视黄酸是维生素A的衍生物，通过在肾和免疫活性细胞（B和T细胞;单核细胞和巨噬细胞）中表达的类维生素A受体发挥作用。在肾小球肾炎和肾间质疾病的实验模型中，类维生素A显示出减少肾小球和肾小管损伤和炎症。因此，我们研究了类维生素A是否减少急性肾移植排斥反应模型中的细胞排斥反应和肾损伤。将Fisher大鼠（F344，RT 1（1v 1））的肾脏原位移植到刘易斯大鼠（RT 1（1））上。移植后7或14天处死动物。接受移植的大鼠用异维A酸（13顺式维甲酸）以2 mg/kg体重/天的低剂量（LD异维A酸）或20 mg/kg体重/天的高剂量（HD异维A酸）或用赋形剂治疗。在第14天，白蛋白尿减少了约70%（载体：1.1+/-0.2mg/24小时对比LD异维甲酸：0.32+/-0.1mg/24小时; P
Background. Retinoic acids, derivatives of vitamin A, act through retinoid receptors that are expressed in renal and immunocompetent cells (B and T cells; monocytes and macrophages). In experimental models of glomerulonephritis and renal interstitial disease, retinoids were shown to reduce both glomerular and tubular damage and inflammation. We therefore examined whether retinoids reduce cellular rejection and renal damage in a model of acute renal allograft rejection.Methods. Kidneys of Fisher rats (F344, RT1(1v1)) were orthotopically grafted to Lewis rats (RT1(1)). Animals were killed 7 or 14 days after transplantation. Rats undergoing transplantation were treated with isotretinoin (13 cis-retinoic acid) at a low dose of 2 mg/kg body weight per day (LD isotretinoin) or at a high dose of 20 mg/kg body weight per day (HD isotretinoin) or with vehicle.Results. At day 14, albuminuria was reduced by approximately 70% (vehicle: 1.1+/-0.2 mg/24 hr vs. LD isotretinoin: 0.32+/-0.1 mg/24 hr; P