Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion
Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion
复制标题
松香素对小鼠脂多糖诱导的内毒素休克的保护作用与细胞因子分泌的调节相关
DOI：
10.3109/1547691x.2013.792886
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发表时间：
2014-01-01
影响因子：
3.3
通讯作者：
Feng, Haihua
中科院分区：
文献类型：
--
作者：
Soromou, Lanan Wassy;Jiang, Lanxiang;Feng, Haihua
Abstract Natural products have been used as potentially important sources of anti-inflammatory drugs. This study examined the effects of pinocembrin against lipopolysaccharide (LPS)-induced endotoxemia to ascertain whether pinocembrin could protect mice from ensuing death. Cytokine responses were also assessed in serum isolated from blood collected at 0, 2, 4, 6, 8, and 24 h after LPS administration of the mice (with or without drug treatment). The results showed that there was a lower production of TNFα, IL-6, and IL-1β in the serum of LPS-challenged mice that had been pre-treated with pinocembrin. In addition, pre-treatment with pinocembrin improved host survival against the LPS-induced lethal endotoxemia. These results suggest that this new flavonoid could potentially be a novel candidate for preventing development/mitigation progression of septic shock.
