Mechanical analysis of atherosclerotic plaques based on optical coherence tomography
Mechanical analysis of atherosclerotic plaques based on optical coherence tomography
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DOI：
10.1114/b:abme.0000049034.75368.4a
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发表时间：
2004-11-01
影响因子：
3.8
通讯作者：
Kaazempur-Mofrad, MR
中科院分区：
文献类型：
--
作者：
Chau, AH;Chan, RC;Kaazempur-Mofrad, MR
有限元分析是研究动脉粥样硬化生物力学的有力工具，从而提高了对急性心肌梗死的认识。传统上，动脉壁的结构分析是使用来自组织学的几何轮廓进行的。在本文中，我们首次使用一种新的成像技术--光学相干层析成像(OCT)作为有限元分析的基础。与组织学相比，OCT有两个主要优点：1)成像无需过多的组织处理，提供了比组织学更逼真的几何形状，并避免了组织学处理中常见的结构伪影；2)OCT成像可以在体内进行，使在动物模型和活体患者中研究疾病进展和治疗效果成为可能。比较基于OCT的有限元分析和基于“金标准”组织学的建模计算的机械应力和应变分布模式。我们的结果表明，OCT测定的血管结构和成分为研究与动脉粥样硬化和急性心肌梗死相关的生物力学因素提供了充分的基础。
Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstrate the first use of a new imaging technique, optical coherence tomography (OCT), as a basis for finite element analysis. There are two primary benefits of OCT relative to histology: 1) imaging is performed without excessive tissue handling, providing a more realistic geometry than histology and avoiding structural artifacts common to histologic processing, and 2) OCT imaging can be performed in vivo, making it possible to study disease progression and the effect of therapeutic treatments in animal models and living patients. Patterns of mechanical stress and strain distributions computed from finite element analysis based on OCT were compared with those from modeling based on "gold standard" histology. Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction.