B lymphocyte - directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
B lymphocyte - directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
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DOI：
10.1038/nm1673
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发表时间：
2007-11-01
期刊：
影响因子：
82.9
通讯作者：
Naji, Ali
中科院分区：
文献类型：
--
作者：
Liu, Chengyang;Noorchashm, Hooman;Naji, Ali
我们发现，由兔抗胸腺细胞球蛋白（Thymoglobulin）和CD20利妥昔单抗（Rituxan）单克隆抗体组成的诱导免疫治疗方案促进了维持雷帕霉素单药治疗的食蟹猴胰岛移植物的长期存活。利妥昔单抗介导的耗竭后B淋巴细胞重建的特征是未成熟和过渡细胞占优势，其持续性与胰岛移植物的长期存活相关。只有在持续雷帕霉素单药治疗的情况下，供体特异性同种抗体的产生才被消除。
We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.