Menstrual cycle characteristics - Associations with fertility and spontaneous abortion
Menstrual cycle characteristics - Associations with fertility and spontaneous abortion
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DOI：
10.1097/01.ede.0000190540.95748.e6
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发表时间：
2006-01-01
期刊：
影响因子：
5.4
通讯作者：
Marcus, M
中科院分区：
文献类型：
--
作者：
Small, CM;Manatunga, AK;Marcus, M
背景资料：流行病学家经常使用月经周期模式的内分泌功能的指标，在环境和职业研究，但很少有研究认为月经周期的特点是否与生育或妊娠outcome.Methods：我们前瞻性研究了470名妇女，以确定是否周期长度或出血长度与生育或自然流产。妇女完成每日日记，包括月经出血、性交、避孕措施使用和协变量的信息。每个月经周期，妇女收集至少2个尿液样本，分析人绒毛膜促性腺激素，以确定早期妊娠。妇女随访1年或直到临床妊娠结束。结果：周期长度为30至31天之前的周期具有最高的生育力。较短的周期不太可能随后受孕（生殖力比[FR] = 0.6; 95%置信区间[CI] = 0.4-1.0）。与30- 31天周期相比，较短和较长周期后的妊娠更容易自然流产（较短周期，OR = 3.0 [95%CI = 0.9-9.6]，较长周期，OR = 3.0 [0.9-10.6]）。月经出血5天的周期具有最高的生殖力。出血时间长达4天的周期具有较低的生殖力（对于出血时间为4天，FR = 0.5 [0.3-0.8]，对于出血时间小于4天，FR = 0.6 [0.3-0.9]）。出血超过5天后，自然流产的可能性较小（OR = 0.4 [0.1-1.1]）相比，5天bleededs.Conclusions：月经周期的特点似乎与生育能力和自然流产。
Background: Epidemiologists often use menstrual cycle patterns as indicators of endocrine function in environmental and occupational studies, yet few studies have considered whether menstrual cycle characteristics are associated with fertility or pregnancy outcome.Methods: We prospectively studied 470 women to determine whether cycle length or bleed length were associated with fertility or spontaneous abortion. Women completed daily diaries with information on menstrual bleeding, intercourse, birth control use, and covariates. For each menstrual cycle, women collected at least 2 urine samples, which were assayed for human chorionic gonadotropin to define early pregnancies. Women were followed for 1 year or until the end of a clinical pregnancy.Results: Cycles with lengths of 30 to 31 days preceded cycles with the highest fecundity. Shorter cycles were less likely to be followed by conception (fecundity ratio [FR] = 0.6; 95% confidence interval [CI] = 0.4-1.0). Compared with 30- to 31-day cycles, conceptions after shorter and longer cycles were more likely to be spontaneously aborted (for shorter cycles, odds ratio [OR] = 3.0 [95% CI = 0.9-9.6] and for longer cycles, OR = 3.0 [0.9-10.6]). Cycles with 5 days of menstrual bleeding had the highest fecundity. Cycles with up to 4 days of bleeding had lower fecundity (for bleed lengths of 4 days, FR = 0.5 [0.3-0.8] and for bleed lengths less than 4 days, FR = 0.6 [0.3-0.9]). Spontaneous abortion was less likely after bleeds greater than 5 days (OR = 0.4 [0.1-1.1]) when compared with 5-day bleeds.Conclusions: Menstrual cycle characteristics appear to be associated with fertility and spontaneous abortion.