Signal duration and the time scale dependence of signal integration in biochemical pathways
Signal duration and the time scale dependence of signal integration in biochemical pathways
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DOI：
10.1186/1752-0509-2-108
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发表时间：
2008-12-17
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通讯作者：
Locasale, Jason W.
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文献类型：
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作者：
Locasale, Jason W.
背景资料：信号持续时间（例如，活性信号传导中间体持续的时间）是无数情况下（如细胞生长、增殖和发育谱系承诺）生物决策的关键调节因子。伴随的信号持续时间的差异是许多下游的生物过程，需要多个步骤的生化regulation.Results：在这里，我们提出了一个分析，探讨如何简单的生化图案，涉及多个阶段的监管可以构建差异处理信号，坚持在不同的时间尺度。我们计算这些网络内的动态、频率依赖性增益和由此产生的功率谱，以更好地理解生化网络如何在不同的时间尺度上整合信号。我们确定这些网络的拓扑特征，允许不同的频率依赖的信号processing properties.Conclusion：我们表明，多级级联是有效的，而在负反馈的存在下操作的多级级联集成信号的持续时间长，有效的集成信号的持续时间短。我们的研究提出了为什么与下游调控的多个步骤有关的信号持续时间是生化系统中普遍存在的基序的原则。
Background: Signal duration (e.g. the time over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proliferation, and developmental lineage commitments. Accompanying differences in signal duration are numerous downstream biological processes that require multiple steps of biochemical regulation.Results: Here we present an analysis that investigates how simple biochemical motifs that involve multiple stages of regulation can be constructed to differentially process signals that persist at different time scales. We compute the dynamic, frequency dependent gain within these networks and resulting power spectra to better understand how biochemical networks can integrate signals at different time scales. We identify topological features of these networks that allow for different frequency dependent signal processing properties.Conclusion: We show that multi-staged cascades are effective in integrating signals of long duration whereas multi-staged cascades that operate in the presence of negative feedback are effective in integrating signals of short duration. Our studies suggest principles for why signal duration in connection with multiple steps of downstream regulation is a ubiquitous motif in biochemical systems.