Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer
Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer
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DOI：
10.1002/jso.23030
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发表时间：
2012-06
影响因子：
2.5
通讯作者：
Ying Wu;S. Yamada;H. Izumi;Zhi Li;S. Shimajiri;Ke-Yong Wang;Yunpeng Liu;K. Kohno;Y. Sasaguri
中科院分区：
文献类型：
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作者：
Ying Wu;S. Yamada;H. Izumi;Zhi Li;S. Shimajiri;Ke-Yong Wang;Yunpeng Liu;K. Kohno;Y. Sasaguri
胃癌(GC)死亡的最重要原因是转移，尽管其潜在的机制仍不清楚。Y-box结合蛋白-1(YB-1)与多种肿瘤的侵袭性和不良预后有关。在这项研究中，我们研究了YB-1的表达与晚期胃癌患者的临床病理特征和转移相关的上皮-间充质转化(EMT)表型的关系。
The most significant cause of gastric cancer (GC) death is metastasis, although the underlying mechanisms remain obscure. Y‐box binding protein‐1 (YB‐1) is associated with tumor aggressiveness and poor prognosis in various cancers. In this study we investigated the relationship between YB‐1 expression and the clinicopathologic features and metastasis‐associated epithelial–mesenchymal transition (EMT) phenotype in advanced GC patients.