Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model
Small Islets are Essential for Successful Intraportal Transplantation in a Diabetes Mouse Model
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DOI：
10.1111/j.1365-3083.2010.02466.x
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发表时间：
2010-12-01
影响因子：
3.7
通讯作者：
Qi, Z.
中科院分区：
文献类型：
--
作者：
Su, Z.;Xia, J.;Qi, Z.
Optimization of islet transplantation protocols is necessary for improved success of treatment for type 1 diabetes. Here, we investigated whether the size of islets transplanted into the portal vein (PV) of the liver can affect engraftment in the early post-transplantation in an experimental mouse model. Small (average diameter < 250 mu m, group A) or large (average diameter > 250 mu m, group B) islets (400 islet equivalents/recipient) purified from normal BALB/c mice were transplanted into syngenic recipients with diabetes induced by STZ. The percentage of mice returning to a non-diabetic status was higher in group A (100%) than that of group B (62.5%). Focal areas of liver necrosis associated with the islets emboli were observed in both groups, but the pathology in group B was significantly worse. Multiple proinflammatory cytokines were significantly higher in group B than that of A at 3 h post-transplantation. Our study determined that the size of islets plays a critical role in the success of intraportal islet transplantation (IPIT) and should be taken into account in future IPIT protocols for the treatment of diabetes.
