Adult Drosophila melanogaster as a model for the study of glucose homeostasis.
Adult Drosophila melanogaster as a model for the study of glucose homeostasis.
复制标题
DOI：
10.18632/aging.100185
复制
发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Fridell YW
中科院分区：
文献类型：
--
作者：
Haselton AT;Fridell YW
果蝇胰岛素样肽（DILP）和脂肪运动激素产生细胞的基因消融以及细胞生物学和代谢测量揭示了营养感应的功能保守性以及哺乳动物和果蝇之间的潜在信号机制。 尽管在了解发育幼虫阶段神经内分泌对营养变化的反应方面取得了重大进展，但我们在此讨论有必要研究由于 DILP 产生细胞 (IPC) 消融而导致的有丝分裂后成体阶段的葡萄糖稳态。 我们最近的研究表明，虽然 IPC 的组成型和成人特异性部分消融都会使这些果蝇出现高血糖和葡萄糖不耐症，但成人特异性 IPC 消融的果蝇仍然对胰岛素敏感。 我们的结果证实了成年果蝇 IPC 在调节葡萄糖稳态方面的作用，并强调了成年果蝇 DILP 作用的复杂性。
Genetic ablation of Drosophila melanogaster insulin-like peptide (DILP) and adipokinetic hormone-producing cells accompanied by cell biological and metabolic measurements have revealed functional conservation in nutrient sensing and the underlying signaling mechanisms between mammal and fruit fly. Despite significant advances gained in understanding the neuroendocrine responses to nutrient changes during developmental larval stages, we discuss here the need for investigating glucose homeostasis in the post-mitotic adult stage as the result of ablation of DILP producing cells (IPCs). Our recent studies demonstrate that while both constitutive and adult-specific partial ablation of IPCs renders those flies hyperglycemic and glucose intolerant, flies with adult-specific IPC ablation remain insulin sensitive. Our results substantiate a role of adult IPCs in modulating aspects of glucose homeostasis and highlight the complexity in DILP action in the adult fly.