FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer
FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer
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DOI：
10.1155/2020/3904947
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发表时间：
2020-06-19
期刊：
影响因子：
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通讯作者：
Wang, Fubo
中科院分区：
文献类型：
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作者：
Cao, Zhi;Xu, Yalong;Wang, Fubo
背景。脂肪酸合成酶（Fatty acid synthase，FATS2）已被认为是前列腺癌（prostate cancer，PCa）的一个预后指标。在这项研究中，我们评估了FcxmRNA和蛋白水平的表达，并评估了FcxmRNA表达与中国汉族男性PCa根治性切除术（RP）治疗预后之间的关系。采用组织芯片（TMA）、TCGA公共数据库、GEO数据库和我们的测序数据，结合临床病理特征，分析FXR的表达谱和预后价值。前列腺癌的临床参数和生化复发与FXR表达相关。在所有公开数据库和我们的测序数据中，肿瘤组织中FGFRmRNA的相对表达均较高（p
Backgrounds. Fatty acid synthase (FASN) has been regarded as a prognostic marker in prostate cancer (PCa). In this study, we evaluated FASN expression at both mRNA and protein levels and assessed the association between FASN expression and prognosis in male Han Chinese with PCa treated with radical prostatectomy (RP).Methods. Expression profile and prognostic value of FASN were analyzed in tissue microarray (TMA) and data retrieved from databases including TCGA public database, GEO database, and our sequencing data with whole clinicopathological characteristics.Results. FASN expression was associated with clinical parameters and biochemical recurrence of prostate cancer. The relative expression of FASN mRNA was higher in the tumor tissue in all public databases and our sequencing data (p