Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits.
Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits.
复制标题
兔心动周期期间肺毛细血管血容量和氧饱和度的分数变化。
DOI：
10.1152/jappl.1997.82.5.1668
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Butler,JP
中科院分区：
文献类型：
--
作者：
Topulos,GP;Lipsky,NR;Lehr,JL;Rogers,RA;Butler,JP
Topulos，乔治P.，尼娜河约翰·利普斯基作者：Rick A. Rogers和James P. Butler。家兔心动周期中肺毛细血管血容量和氧饱和度的分数变化。应用生理学杂志82（5）：1668-1676，1997。-在活体动物中，局部肺毛细血管血容量（Vc）和氧饱和度（S）的变化难以测量。通过利用在两个波长（650和800 nm）的光的吸收的差异，我们估计的Vc和S的分数变化在8个麻醉，通气兔在低和高肺容量的心动周期的过程中。通过开胸术，将点光源置于胸膜表面，照射1.01-cm 3肺，观察弥漫后向散射光的模式。在低肺容量时，Vc的分数变化为1.13%，S的变化为1.44%，平均S接近77%。Vc和S的波动分别滞后于峰值全身血压约五分之一和五分之三的周期。在高肺容量时，Vc或S无重要波动，平均S为1.82%。这些结果与心动周期内肺毛细血管压力和气体交换的波动以及随着肺容量增加而降低的毛细血管顺应性一致。
Topulos, George P., Nina R. Lipsky, John L. Lehr, Rick A. Rogers, and James P. Butler.Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits.J. Appl. Physiol.82(5): 1668–1676, 1997.—Changes in local pulmonary capillary blood volume (Vc) and oxygen saturation (S) have been difficult to measure in live animals. By utilizing the differences in absorption of light at two wavelengths (650 and 800 nm), we estimated the fractional change in Vc and S during the course of the cardiac cycle in eight anesthetized, ventilated rabbits at low and high lung volumes. Observations were made of the pattern of diffusely backscattered light, from an ∼1-cm3volume of lung illuminated with a point source placed on the pleural surface through a thoracotomy. At low lung volume, the fractional change in Vc was ∼13%, the change in S was ∼4.6%, and the mean S was close to 77%. The fluctuations in Vc and S lagged behind peak systemic blood pressure by about one-fifth and three-fifths of a cycle, respectively. At high lung volume, there were no important fluctuations in Vc or S, and the mean S was ∼82%. These results are consistent with fluctuations in pulmonary capillary pressure and gas exchange over the cardiac cycle, and with decreasing capillary compliance with increasing lung volume.