The association of sleep-disordered breathing and sleep symptoms with quality of life in the sleep heart health study
The association of sleep-disordered breathing and sleep symptoms with quality of life in the sleep heart health study
复制标题
DOI：
10.1093/sleep/24.1.96
复制
发表时间：
2001-02-01
期刊：
影响因子：
5.6
通讯作者：
Redline, S
中科院分区：
文献类型：
--
作者：
Baldwin, CM;Griffith, KA;Redline, S
这项研究使用SF-36评估了睡眠呼吸紊乱(SDB)、启动和维持睡眠困难(DIMS)以及日间过度嗜睡(EDS)与生活质量(QOL)损害的程度。参与者(n=5,816；平均年龄=63岁；52.5%的女性)参加了一项以全国人群为基础的睡眠心脏健康研究(SHHS)，该研究旨在调查睡眠障碍呼吸作为心血管疾病发展的危险因素。以睡眠和其他潜在的混杂变量(如年龄、种族)为自变量，采用多元Logistic回归分析对每个转换后的SF-36量表进行独立分析。男性(11.6%)明显比女性(5.6%)更有可能患有SDB，而女性(42.4%)明显比男性(32.5%)更有可能报告糖尿病。生命力是唯一与SDB临床类型(轻度、中度、重度SDB)呈线性相关的SF-36量表。然而，严重SDB的个体在多个SF-36量表上显示出显著较差的生活质量。即使在调整了男女的混杂变量后，DIMS和EDS也与降低的生活质量密切相关。研究结果表明，1)轻到中度的SDB与活力降低有关，而严重的SDB更广泛地与较差的生活质量相关，2)主观睡眠症状与较差的生活质量全面相关，以及3)SF-36 SDB和睡眠症状的平均得分与美国普通人群中的其他慢性病相当。
This study assessed the extent to which sleep-disordered breathing (SDB), difficulty initiating and maintaining sleep (DIMS), and excessive daytime sleepiness (EDS) were associated with impairment of quality of life (QoL) using the SF-36. Participants (n=5,816; mean age=63 years; 52.5% women) were enrolled in the nation-wide population-based Sleep Heart Health Study (SHHS) implemented to investigate sleep-disordered breathing as a risk factor in the development of cardiovascular disease. Each transformed SF-36 scale was analyzed independently using multiple logistic regression analysis with sleep and other potential confounding variables (e.g., age, ethnicity) included as independent variables. Men (11.6%) were significantly more likely to have SDB compared to women (5.6%), while women (42.4%) were significantly more likely to report DIMS than men (32.5%). Vitality was the sole SF-36 scale to have a linear association with the clinical categories of SDB (mild, moderate, severe SDB). However, individuals with severe SDB indicated significantly poorer QoL on several SF-36 scales. Both DIMS and EDS were strongly associated with reduced QoL even after adjusting for confounding variables for both sexes. Findings suggest 1) mild to moderate SDB is associated with reduced vitality, while severe SDB is more broadly associated with poorer QoL, 2) subjective sleep symptoms are comprehensively associated with poorer Qol, and 3) SF-36 mean score profiles for SDB and sleep symptoms are equivalent to other chronic diseases in the U.S. general population.