Age-related changes in corneal thickness and endothelial characteristics.
Age-related changes in corneal thickness and endothelial characteristics.
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DOI：
10.2147/cia.s51693
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发表时间：
2013
影响因子：
3.6
通讯作者：
Ašoklis RS
中科院分区：
文献类型：
--
作者：
Galgauskas S;Norvydaitė D;Krasauskaitė D;Stech S;Ašoklis RS
确定年龄对中央角膜厚度（CCT）、内皮细胞密度（ECD）、平均细胞大小、细胞大小变异系数和正六边形细胞百分比的影响，并估计7个年龄组的平均ECD和CCT。在获得知情同意后，在维尔纽斯大学医院Santariskiu诊所的眼科疾病中心使用非接触式角膜内皮显微镜对211例白人患者（358只眼）进行了检查。主要角膜参数包括：ECD、平均细胞大小、细胞大小变异系数、正六边形细胞百分比和CCT。受试者（20-89岁）按年龄分为7组。发现CCT、内皮参数（ECD、正六边形细胞百分比、平均值、变异系数）和年龄之间存在相关性，并计算Student t检验和Pearson相关系数（r）值。共有114名（54.03%）女性和97名（45.97%）男性参与了研究。平均ECD（细胞/mm 2）范围为20-29奥尔兹的2，931（±371）至80-89奥尔兹的2，222（±182）; CCT（μm）范围为20-29奥尔兹的563（±44）至80-89奥尔兹的540（±35）。年龄与角膜ECD呈强负相关（r=-0.650，P<0.01），年龄与CCT呈弱负相关（r=-0.156，P<0.01）。ECD与CCT呈正相关（r=0.232，P<0.01）。角膜内皮细胞平均大小与年龄呈正相关（r=0.586，P<0.01）。细胞大小变异系数和正六边形细胞百分率与年龄无关（P>0.05）。年轻人的ECD更高。CCT也降低，但对年龄的依赖性较弱。较低的细胞密度表明角膜较薄。细胞大小和正六边形细胞百分比的变化不依赖于年龄。
To determine the influence of age on central corneal thickness (CCT), endothelial cell density (ECD), average cell size, coefficient of variation in cell size, and percentage of regular hexagonal cells; and to estimate the average ECD and CCT in seven age groups. After obtaining informed consent, 211 Caucasian patients (358 eyes) were examined using a noncontact specular microscope at the Center of Eye Diseases in Vilnius University Hospital Santariskiu Clinic. The main corneal parameters were: ECD, average cell size, coefficient of variation in cell size, percentage of regular hexagonal cells, and CCT. Subjects (20–89 years) were stratified by age into seven groups. Correlations between CCT, endothelial parameters (ECD, percentage of regular hexagonal cells, average, coefficient of variation), and age were found. Student’s t-test and Pearson’s correlation coefficient (r) values were calculated. A total of 114 (54.03%) women and 97 (45.97%) men participated in the study. Average ECD (cell/mm2) ranged from 2,931 (±371) in 20–29 year olds to 2,222 (±182) in 80–89 year olds; CCT (μm) ranged from 563 (±44) in 20–29 year olds to 540 (±35) in 80–89 year olds. A strong inverse correlation was observed between age and corneal ECD (r=−0.650, P<0.01) and a weak inverse correlation was observed between age and CCT (r=−0.156, P<0.01). ECD and CCT correlated directly (r=0.232, P<0.01). The average size of corneal endothelial cells directly correlated with age (r=0.586, P<0.01). There was no correlation between age and the coefficient of variation in cell size nor the percentage of regular hexagonal cells (P>0.05). Young people have higher ECD. CCT also decreases, but its dependence on age is weaker. A lower cell density indicates a thinner cornea. The variation in cell size and percentage of regular hexagonal cells are not dependent on age.