Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
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DOI：
10.1111/cas.12442
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发表时间：
2014-07
期刊：
影响因子：
5.7
通讯作者：
Seto M
中科院分区：
文献类型：
--
作者：
Suguro M;Yoshida N;Umino A;Kato H;Tagawa H;Nakagawa M;Fukuhara N;Karnan S;Takeuchi I;Hocking TD;Arita K;Karube K;Tsuzuki S;Nakamura S;Kinoshita T;Seto M
淋巴细胞恶性肿瘤的克隆异质性最近在成人t细胞淋巴瘤/白血病、外周t细胞淋巴瘤和套细胞淋巴瘤中有报道。我们的分析扩展到其他类型的淋巴瘤，包括边缘带淋巴瘤、滤泡性淋巴瘤和弥漫性大b细胞淋巴瘤。为了确定克隆异质性的存在，我们对332例患者进行了阵列比较基因组杂交分析。结果显示，不同类型淋巴瘤的克隆异质性发生率从25%到69%不等。生存分析显示，克隆异质性的套细胞淋巴瘤和弥漫性大b细胞淋巴瘤的预后明显较差，克隆异质性被证实是两种类型淋巴瘤预后不良的独立预测因子。有趣的是，8q24.1 （MYC）增加，9p21.3 （CDKN2A/2B）丢失和17p13 （TP53, ATP1B2, SAT2， SHBG）丢失是各种类型的具有克隆异质性的淋巴瘤的复发性基因组病变，至少部分表明这些基因的改变可能在克隆异质性中起作用。
Clonal heterogeneity in lymphoid malignancies has been recently reported in adult T-cell lymphoma/leukemia, peripheral T-cell lymphoma, not otherwise specified, and mantle cell lymphoma. Our analysis was extended to other types of lymphoma including marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma. To determine the presence of clonal heterogeneity, 332 cases were examined using array comparative genomic hybridization analysis. Results showed that incidence of clonal heterogeneity varied from 25% to 69% among different types of lymphoma. Survival analysis revealed that mantle cell lymphoma and diffuse large B-cell lymphoma with clonal heterogeneity showed significantly poorer prognosis, and that clonal heterogeneity was confirmed as an independent predictor of poor prognosis for both types of lymphoma. Interestingly, 8q24.1 (MYC) gain, 9p21.3 (CDKN2A/2B) loss and 17p13 (TP53, ATP1B2, SAT2, SHBG) loss were recurrent genomic lesions among various types of lymphoma with clonal heterogeneity, suggesting at least in part that alterations of these genes may play a role in clonal heterogeneity.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
45.3
作者：
Beà, S;Colomo, L;Campo, E
通讯作者：
Campo, E
影响因子：
3.1
作者：
Liu, Fang;Yoshida, Noriaki;Seto, Masao
通讯作者：
Seto, Masao
影响因子：
7.5
作者：
Braggio, Esteban;Dogan, Ahmet;Fonseca, Rafael
通讯作者：
Fonseca, Rafael
DOI：
10.1084/jem.20110921
发表时间：
2011-07-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fabbri G;Rasi S;Rossi D;Trifonov V;Khiabanian H;Ma J;Grunn A;Fangazio M;Capello D;Monti S;Cresta S;Gargiulo E;Forconi F;Guarini A;Arcaini L;Paulli M;Laurenti L;Larocca LM;Marasca R;Gattei V;Oscier D;Bertoni F;Mullighan CG;Foá R;Pasqualucci L;Rabadan R;Dalla-Favera R;Gaidano G
通讯作者：
Gaidano G